Packaging cell lines for adeno-associated viral vectors

Details Packaging cell lines for adeno-associated viral vectors Packaging cell lines for adeno-associated viral vectors

1995-05-12

1999-02-16

Ketter, James

Chemistry: molecular biology and microbiology

Vector, per se

435369, C12N 1500, C12N 508

Patent

active

058720057

ABSTRACT:
The present invention is directed to novel replication-deficient adenoviral vectors characterized in that they harbor at least two lethal early region gene deletions (E1 and E4) that normally transcribe adenoviral early proteins. These novel recombinant vectors find particular use in human gene therapy treatment whereby the vectors additionally carry a transgene or therapeutic gene that replaces the E1 or E4 regions. The present invention is further directed to novel packaging cell lines that are transformed at a minimum with the adenoviral E1 and E4 gene regions and function to propagate the above novel replication-deficient adenoviral vectors.

REFERENCES:
patent: 5354678 (1994-10-01), Lebkowski et al.
patent: 5436146 (1995-07-01), Shenk et al.
patent: 5474935 (1995-12-01), Chatterjee et al.
Hermonat et al. 1984 Journal of Virology 51(2) 329-339.
Su et al. 1992 Biochem/Biophys. Res. Comm. 186(1) 293-300.
Gossen et al. 1992 Proc. Nat'l Acad. Sci 89: 5547-5551.
Janik et al. 1989 Virology 168:320-329.

Affiliated with

Also associated with

Rating

Packaging cell lines for adeno-associated viral vectors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Packaging cell lines for adeno-associated viral vectors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Packaging cell lines for adeno-associated viral vectors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2061629