[(Oxyalkyl)thioacetyl]cephalosporin derivatives

Details [(Oxyalkyl)thioacetyl]cephalosporin derivatives [(Oxyalkyl)thioacetyl]cephalosporin derivatives

1975-05-01

1976-11-09

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260470, 260481R, 260516, 260535S, 260544Y, 424246, C07D50128, C07D50132

Patent

active

039910512

ABSTRACT:
[(Oxyalkyl)thioacetyl] cephalosporin derivatives having the formula ##EQU1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, tri(lower alkyl)silyl, a salt forming ion, or the group ##EQU2## R.sub.1 is hydrogen, lower alkyl, phenyl, thienyl or furyl; R.sub.2 and R.sub.6 each is hydrogen or lower alkyl; R.sub.3 and R.sub.5 each is lower alkyl, phenyl or phenyl-lower alkyl; and R.sub.4 is hydrogen, hydroxy, lower alkanoyloxy, lower alkoxy or lower alkylthio; are useful as antimicrobial agents.

REFERENCES:
patent: 3338897 (1967-08-01), Takano et al.
Sassiver et al., Antimicrobial Agents & Chemeotherapy, 1968, pp. 101-108 (1969).

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