Oxy substituted chalcones as antihyperglycemic and...

Details Oxy substituted chalcones as antihyperglycemic and... Oxy substituted chalcones as antihyperglycemic and...

2004-12-22

2010-10-05

Wilson, James O (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S369000, C514S652000, C549S434000, C568S334000

Reexamination Certificate

active

07807712

ABSTRACT:
The present invention provides appropriately substituted chalcones, such as, for example, represented by the structural formula as shown herein belowWherein R1, R2 and R3 are selected from the group consisting of H, OH, O-alkyl, O-phenyl and O-substituted phenyl; B represents Ar—Z—O or RO; where Z is an alkane having up to 5 carbon atoms; R is substituted propanol amino, wherein substituted amino groups are selected from the group consisting of t-butyl, n-butyl, i-butyl, i-propyl, 4-phenyl piperazine-1-yl, 4-(2-methoxyphenyl)-piperazin-1-yl and 3,4-dimethoxy phenethyl; and Ar is thiazolidine-dione methylene phenoxy. The compounds prepared have been demonstrated to exhibit significant antidiabetic effect in various animal models indicating potential for further exploitation.

REFERENCES:
Palanowski et. al., Acta Poloniae Pharmaceutica, 1967, 24(6), 567-574.
Rastogi et. al., J. Med. Chem., 1972, 15(3), 286-291.
Satyanarayana et. al., Bioorg. & Med. Chem., 2004, 12, 883-889.

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