Oxotitanium complex, asymmetric hydrogenation catalyst comprisin

Details Oxotitanium complex, asymmetric hydrogenation catalyst comprisin Oxotitanium complex, asymmetric hydrogenation catalyst comprisin

1995-03-10

1997-04-01

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heavy metal containing

C07F 700

Patent

active

056167512

ABSTRACT:
A novel oxotitanium complex represented by general formula (I) is disclosed: ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and each represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom, a phenyl group, a substituted phenyl group, a trialkylsilyl group, a monoalkyldiphenylsilyl group, a dialkylmonophenylsilyl group, a triphenylsilyl group, a substituted triphenylsilyl group, or a lower alkoxycarbonyl group, provided that R.sup.1 and R.sup.2 may be bonded to each other to form a hydrocarbon ring or a substituted hydrocarbon ring in cooperation with the carbon atoms to which R.sup.1 and R.sup.2 are bonded; R.sup.3 and R.sup.4 may be the same or different and each represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a benzoyl group, a benzenesulfonyl group, or a halogen atom, provided that R.sup.3 and R.sup.4 may be bonded to each other to form a hydrocarbon ring or a substituted hydrocarbon ring in cooperation with the carbon atoms to which R.sup.3 and R.sup.4 are bonded; and n is 1 or 2. The novel oxotitanium complex is useful as an asymmetric reaction catalyst. A process for producing a .beta.-hydroxy ketone or an .alpha.-hydroxy carboxylic acid ester in the presence of the novel oxotitanium complex is also disclosed.

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Journal of the Chemical Society, Chem. Comm. No. 7, Apr. 7, 1994, pp. 833-834, XP002003784, M. Terana at al "Binaphthol-Derived Titanium Mu-Oxo Complex . . . Reaction with Glycolate".
Journal of the American Chemical Society, vol. 117, No. 11, Feb. 22, 1995, pp. 3008-2031, XP002003785, A. Van Der Linden et al, "Polymerization of .alpha.-Olefins and Butadiene and Catalytic . . . Zirconium Species".

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