Treatment for secondary diabetes effects

Details Treatment for secondary diabetes effects Treatment for secondary diabetes effects

1988-10-31

1991-09-10

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

H61K 3119

Patent

active

050474278

ABSTRACT:
The invention provides a method to ameliorate or prevent the secondary damaging effects of diabetes by affecting oxidation of sorbitol in insulin-independent cells. Pyruvate salts and/or NAD.sup.+ precursors administered in a repetitive protocol provide protection against these secondary effects.

REFERENCES:
Gonzalez et al., (1986), Diabetes, 35:1200-1205.
Varma et al., (1974), Biochim. Biopys. Acta, 338:632-640.
Greene et al., (1985), Diabetes Care 8, (3):290-299.
Travis et al., The Journal of Clinical Investigation, (1971), 50:2104-2112.
McLean et al., Diabetic Medicine, (1978), 2:189-193.
Goheen et al., Lipids, (1981), 16:1:43-51.
Stanko et al., Metabolism, (1986), 35:2:182-186.
Stanko et al., J. Lab. Clin. Med., (1978), 91:2:228-235.
Williamson, Abstract for 1988 Meeting of the American Diabetes Association, Inc.
Kinoshita et al., (1979), Metabolism 28, suppl. 1., pp. 462-469.
Tilton et al., (1988), Investigative Opthalmology and Visual Science, 29(6):861-868.
Williamson et al., (1988), Diabetes/Metabolism Reviews, 4(4)339-370.

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