Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-12-18
1992-02-11
Gerstl, Robert
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514360, 546280, 548122, C07D29104, A61K 3141
Patent
active
050876317
ABSTRACT:
The present invention relates to the compounds of formula (I). ##STR1## wherein R.sup.1 is C.sub.1-8 alkyl, C.sub.2-8 alkenyl, C.sub.5-8 cycloalkyl, aryl-C.sub.1-4 alkyl, aryl or heteroaryl; or aryl or heteroaryl which is mono-, di-, or trisubstituted independently with halogen, nitro, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, trifluoromethyl, amino or C.sub.1-4 alkyl mono or disubstituted amino, pharmaceutical formulations containing these compounds and their use as vasodilators in the treatment of cardiovascular disorders.
REFERENCES:
J. Pharm. Pharmasol., J. R. Parratt, 31, 801 (1979).
Pharm. Res., L. J. Ignarro, 6, 651 (1989).
Annu. Rev. Physiol., K. E. Kamm, et al., 51, 299 (1989).
Liebigs Ann. Chem., H. Gotthardt, et al., 1025 (1981).
Chem. Ber., H. Gotthardt, 105, 188 (1972).
Tetrahedron Letters, H. Gotthardt, No. 17, 1277 (1971).
J. Am. Chem. Soc., A. Holm, et al., 97, No. 21, 6197 (1975).
Tetrahedron, A. Holm, 32, 2559 (1976).
Shaffer Joel E.
Thomson Stephen A.
Gerstl Robert
Glaxo Inc.
Joyner Charles T.
LandOfFree
Oxathi(SIV)azol-5-one compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Oxathi(SIV)azol-5-one compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Oxathi(SIV)azol-5-one compounds will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-782066