Oxadiazolidinedione compound

Details Oxadiazolidinedione compound Oxadiazolidinedione compound

2011-06-28

2011-06-28

Chu, Yong (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S340000, C514S364000, C544S333000, C546S269100, C548S132000

Reexamination Certificate

active

07968552

ABSTRACT:
A compound which can be used as a pharmaceutical, particularly a insulin secretion promoter or a agent for preventing/treating disease in which GPR40 is concerned such as diabetes or the like, is provided.It was found that an oxadiazolidinedione compound which is characterized by the possession of a benzyl or the like substituent binding to the cyclic group via a linker at the 2-position of the oxadiazolidinedione ring, or a pharmaceutically acceptable salt thereof, has excellent GPR40 agonist action. In addition, since the oxadiazolidinedione compound of the present invention showed excellent insulin secretion promoting action and blood glucose level-lowering action, it is useful as an insulin secretion promoter or an agent for preventing/treating diabetes.

REFERENCES:
patent: 5480896 (1996-01-01), Malamas et al.
patent: 5885997 (1999-03-01), Lohray et al.
patent: 6288096 (2001-09-01), Andersson et al.
patent: 2005/0113428 (2005-05-01), Gopalsamy et al.
patent: 0 696 585 (1996-02-01), None
patent: 1 559 422 (2005-08-01), None
patent: 1 726 580 (2006-11-01), None
patent: 7-2848 (1995-01-01), None
patent: 8-59638 (1996-03-01), None
patent: H10-502907 (1998-03-01), None
patent: 2000-212174 (2000-08-01), None
patent: 2002-503255 (2002-01-01), None
patent: 2002-515874 (2002-05-01), None
patent: 2005-015461 (2005-01-01), None
patent: 2 135 487 (1999-08-01), None
patent: WO 94/025448 (1994-11-01), None
patent: WO 95/30664 (1995-11-01), None
patent: WO 97/41097 (1997-11-01), None
patent: WO 98/57941 (1998-12-01), None
patent: WO 2004041266 (2004-05-01), None
patent: WO 2005/030203 (2005-04-01), None
patent: WO 2005/063725 (2005-07-01), None
patent: WO 2005/063729 (2005-07-01), None
patent: WO 2005/086661 (2005-09-01), None
Preliminary STN search report—12298522—04242010.
Padwal et al. Diabetes Care, vol. 28 (3), p. 736-744, (2005), at p. 736.
Y. Itoh et al., “Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40”, Nature, vol. 422, pp. 173-176 (2003).
Michael S. Malamas, et al., “Antihyperglycemic activity of new 1,2,4-oxadiazolidine-3,5-diones”, European Journal of Medicinal Chemistry, vol. 36, pp. 31-42 (2001).
Stuart W. Bright et al., “Monoclonal Antibodies as Surrogate Receptors in a high throughput screen for compounds that enhance insulin sensitivity”, Life Sciences, vol. 61, pp. 2305-2315 (1997).
Guarram R. Madhavan et al., “Synthesis and Biological Actiity of Novel Pyrimidinone Containing Thiazolidinedione Derivatives”, Bioorganic & Medicinal Chemistry, vol. 10, pp. 2671-2680 (2002).
Examination Report mailed Jun. 1, 2010, by the Intellectual Property Office of New Zealand in corresponding Application No. 572146.
Official Action in corresponding Indonesian Application No. W-00 2008 03450, dated Sep. 6, 2010.
Supplementary European Search Report mailed Sep. 9, 2010, in corresponding EP Application No. 07742129.5-2101.
Office Action mailed Dec. 9, 2010, in corresponding Chinese Patent Application No. 200780014661.8.
Official Action mailed Mar. 16, 2011, in corresponding Russian Patent Application No. 2008146088/04(060236), Russian Agency for Patents and Trademarks.

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