Osteoclast differentiation inhibitors

Details Osteoclast differentiation inhibitors Osteoclast differentiation inhibitors

2006-06-13

2006-06-13

Habte, Kahsay (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

C544S102000, C435S118000

Reexamination Certificate

active

07060821

ABSTRACT:
A compound represented by formula (I); a process for producing a compound (substance F-1490) of formula (I), wherein X represents —O— and R represents a hydroxyl group, by using a microorganism belonging to the genusCunninghamella; and aCunninghamellasp. F-1490 strain (FERM BP-8287) capable of producing the substance F-1490; and an osteoclast differentiation inhibitory agent containing as an active ingredient the compound represented by formula (I):wherein X represents —O— or —CH2—, and R represents a hydroxyl group when X represents —O—, or a hydrogen atom when X represents —CH2—.

REFERENCES:
Inoue et al. J. Antibiot (Tokyo) Mar. 2003; 56(3):209-13.
Someno et al. J. Antibiot (Tokyo) Mar. 2003; 56(3):214-218.
Levine S.G. et al—Structure of the o-Aminophenol-Adipoin Condensation Product—J. Org. Chem. 1976, vol. 41, No. 25, p. 4026-4028.
Herzig C. et al—2-Chlorooxirane als Synthone zur Darstellung sechsgliedriger Heterocyclen—Chem. Ber. 1981, vol. 114, N. 6, p. 2348-2354.

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