Ortho-substituted benzoylguanidines, including composition and m

Details Ortho-substituted benzoylguanidines, including composition and m Ortho-substituted benzoylguanidines, including composition and m

1997-02-24

1999-10-12

Higel, Floyd D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

514280, 514351, 514399, 514400, 514617, 5483361, 564 37, 564 85, 564153, 564157, 564183, C07C27922, C07C27708, C07D40114, C07D40312, A61K 31495, A61K 31155

Patent

active

059657448

ABSTRACT:
The present invention relates to ortho-substituted benzoylguanidines of the formula I, defined in the specification. The invention also embraces processes for making these compounds, as well as compositions and methods of using them. The compounds of the invention exhibit very good antiarrhythmic properties, making them useful in treating or preventing infarction, angina pectoris, and pathophysiological processes associated with ischemically induced damage.

REFERENCES:
patent: 3780027 (1973-12-01), Cragoe et al.
patent: 5091394 (1992-02-01), Englert et al.
patent: 5516805 (1996-05-01), Lang et al.
Mildner et al., "Inhibition of Urease by Some Triazole, Urea, and Guanidine Derivatives," Croatica Chemica Acta, 46(1):79-82 (1974).
Englert et al II, Chemical Abstracts, vol. 115, #71158m (1991).
Lang et al II, Chemical Abstracts, vol. 119, #270818j (1993).

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