Ortho-substituted benzoylguanidines, a process for their prepara

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

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514317, 514522, 514603, 514618, 514821, 514825, 546233, 558413, 564 85, 564 86, 564134, 564139, 564142, 564144, 564162, 564164, 564165, C07C27922, C07C27708, A61K 31165, A61K 3118

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06001881&

ABSTRACT:
Benzoylguanidines of the formula I ##STR1## in which: R(1) to R(4) have the meanings given in the claims, are antiarrhythmic pharmaceuticals, having a cardioprotective component, which are also valuable for the prevention of ischemically induced damage, in particular in association with the triggering of ischemically induced cardiac arrhythmias. As a consequence of inhibiting the cellular Na.sup.+ /H.sup.+ exchange mechanism, they are used for treating acute or chronic damage triggered by ischemia. In addition to this, they are notable for their strong inhibitory effect on the proliferation of cells. They are suitable for preventing the genesis of high blood pressure.

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