Radiant energy – Inspection of solids or liquids by charged particles – Methods
Patent
1997-11-25
1999-11-23
Berman, Jack I.
Radiant energy
Inspection of solids or liquids by charged particles
Methods
2504591, 356317, 422 8208, 25230117, 378 47, 436546, G01N 130, G01N 2163
Patent
active
059904798
ABSTRACT:
A luminescent semiconductor nanocrystal compound is described which is capable of linking to an affinity molecule. The compound comprises (1) a semiconductor nanocrystal capable of emitting electromagnetic radiation (luminescing) in a narrow wavelength band and/or absorbing energy, and/or scattering or diffracting electromagnetic radiation--when excited by an electromagnetic radiation source (of narrow or broad bandwidth) or a particle beam; and (2) at least one linking agent, having a first portion linked to the semiconductor nanocrystal and a second portion capable of linking to an affinity molecule. The luminescent semiconductor nanocrystal compound is linked to an affinity molecule to form an organo luminescent semiconductor nanocrystal probe capable of bonding with a detectable substance in a material being analyzed, and capable of emitting electromagnetic radiation in a narrow wavelength band and/or absorbing, scattering, or diffracting energy when excited by an electromagnetic radiation source (of narrow or broad bandwidth) or a particle beam. The probe is stable to repeated exposure to light in the presence of oxygen and/or other radicals.
Further described is a process for making the luminescent semiconductor nanocrystal compound and for making the organo luminescent semiconductor nanocrystal probe comprising the luminescent semiconductor nanocrystal compound linked to an affinity molecule capable of bonding to a detectable substance. A process is also described for using the probe to determine the presence of a detectable substance in a material.
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Alivisatos Paul
Bruchez, Jr. Marcel
Weiss Shimon
Berman Jack I.
Martin Paul R.
Regents of the University of California
Taylor John P.
Taylor Kerry S.
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