Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1996-12-23
1998-07-21
Peselev, Elli
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 54, 536 21, 536 54, 536 55, 536 551, 536 552, A61K 3170, C08B 3710
Patent
active
057835705
ABSTRACT:
The present invention relates to an organic solvent-soluble mucopolysaccharide consisting of an ionic complex of at least one mucopolysaccharide (preferably heparin or heparin derivative) and a quaternary phosphonium, an antibacterial antithrombogenic composition comprising said organic solvent-soluble mucopolysaccharide and an organic polymer material, an antibacterial antithrombogenic composition comprising said organic solvent-soluble mucopolysaccharide and an antibacterial agent (preferably inorganic antibacterial agent such as silver zeolite), and to a medical material comprising said organic solvent-soluble mucopolysaccharide. The organic solvent-soluble mucopolysaccharide, and the antibacterial antithrombogenic composition and medical material containing the same, of the present invention, can easily impart antithrombogenicity and antibacterial property to a polymer to be a base material, which properties being maintained not only immediately after preparation of the material but also after long-term elution. Thus, the organic solvent-soluble mucopolysaccharide and antibacterial antithrombogenic material of the present invention show superior applicability as a material to impart antithrombogenicity and antibacterial ability to medical materials.
REFERENCES:
patent: 4273873 (1981-06-01), Takagi et al.
Polymeric Phosphonium Salts as a Novel Class of Cationic Biocides; Akihiko Kanazawa, Tomiki Ikeda, and Takeshi Endo; Journal of Polymer Science: Part A: Polymer chemistry, vol. 32, 1997-2001 (1994).
Polymeric Phosphonium Salts as a Novel Class of Cationic Biocides; Akihiko Kanazawa, Tomiki Ikeda, and Takeshi Endo; Journal of Applied Polymer Science, vol. 53, 1245-1249 (1994).
Synthesis and Antimicrobial Activity of Dimethyl-and Trimethyl-Substituted Phosphonium Salts with Alkyl Chains of Various Lengths; Akihiko Kanazawa, Tomiki Ikeda and Takeshi Endo; Antimicrobial Agents and Chemotherapy, May 1994, 945-952.
Polymeric Phosphonium Salts as a Novel Class of Cationic Biocides: Akihiko Kanazawa, Tomiki Ikeda, and Takeshi Endo; Journal of Polymer Science: Part A: Polymer Chemistry, vol. 31, 3031-3038 (1993).
Polymeric Phosphonium Salts as a Novel Class of Cationic Biocides; Akihiko Kanazawa, Tomiki Ikeda, and Takeshi Endo; Journal of Polymer Science: Part A: Polymer Chemistry, vol. 31, 3003-3011 (1993).
Polymeric Phosphonium Salts as a novel Class of Cationic Biocides; Akihiko Kanazawa, Tomiki Ikeda, and Takeshi Endo; Journal of Polymer Science: Part A: Polymer Chemistry, vol. 31, 1467-1472 (1993).
Poilymeric Phosphonium Salts as a Novel Class of Cationic Biocides; Akihiko Kanazawa, Tomiki Ideka, and Takeshi Endo; Journal of Polymer Science: Part A: Polymer Chemistry, vol. 31, 1441-1447 (1993).
Novel Polycationic Biocides: Synthesis and Antibacterial Activity of Polymeric Phosphonium Salts; Journal of Polymer Science: Part A: Polymer Chemistry, vol. 31, 335-343 (1993).
Arimori Susumu
Konagaya Shigeji
Monden Noriko
Seko Masahiro
Tanaka Masakazu
Peselev Elli
Toyo Boseki Kabushiki Kaisha
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