Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1989-09-26
1991-05-14
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514414, 514444, 514445, 514447, 514448, 514326, 544145, 544379, 546207, 546208, 546209, 546210, 546211, 546212, 5482622, 548336, 548374, 548527, 549 55, 549 63, 549 64, 549 76, A61K 3138, C07D40500, C07D40900, C07D33322
Patent
active
050156560
ABSTRACT:
A pharmaceutical compound of the formula ##STR1## in which R.sup.1, R.sup.2 and R.sup.3 independently are hydrogen, hydroxy, halo, nitro, amino, C.sub.2-5 acylamino, C.sub.1-4 alkyl, --CHO, --CH.sub.2 OH, --CH.sub.2 OC.sub.1-4 alkyl, --COOH, --COC.sub.1-3 alkyl, --CH(OH)C.sub.1-3 alkyl, C.sub.1-4 alkoxy, C.sub.2-4 alkenyloxy, C.sub.1-4 alkylthio, C.sub.1-4 alkylsulphinyl, C.sub.1-4 alkylsulphonyl, N-substituted heterocyclyl, optionally substituted phenyl, optionally substituted phenylthio, optionally substituted phenylsulphinyl, optionally substituted phenylsulphonyl or optionally substituted phenylsulphonamido, or R.sup.1 and R.sup.2 together form a C.sub.3-5 alkylene bridge; provided that at least one of R.sup.2 and R.sup.3 is C.sub.1-4 alkoxy or C.sub.2-4 alkenyloxy; and X is (i) --(CH.sub.2).sub.n N(R.sup.4).sub.2 where each R.sup.4 independently is C.sub.1-4 alkyl, C.sub.2-4 alkenyl or optionally substituted C.sub.6 H.sub.5 CH.sub.2 --, and n is 1, 2 or 3, or (ii) a 5- to 8-membered alicyclic group containing one or two nitrogen atoms and directly attached to the amido nitrogen or attached by a C.sub.1-3 alkylene chain; and salts and esters thereof.
REFERENCES:
patent: 3177252 (1965-04-01), Thominet
patent: 3342826 (1967-09-01), Miller et al.
patent: 3932503 (1976-01-01), Weber et al.
patent: 4123550 (1978-10-01), Untch et al.
patent: 4221815 (1980-09-01), Weyer et al.
patent: 4321378 (1982-03-01), Dostert et al.
patent: 4382929 (1983-05-01), Bradshaw et al.
patent: 4560751 (1985-12-01), Seybold
patent: 4777179 (1988-11-01), Bradshaw et al.
patent: 4904686 (1990-02-01), Fernandez et al.
Consiglio et al., J. Chem. Soc. Perkin Trans. II, 1983, 1559-61.
C.A. 72, 3226a (1970).
C.A. 67, 2167w (1967).
C.A. 101, 122562j (1984).
C.A. 100, 84964m (1984).
Anales de la Real Academic de Pharmacia, 42, (4), 563 (1976), (Chemical Abstracts 87: 23197e).
Anales de Quimica, 70 (12), 974, (1974), (Chemical Abstracts 83: 178980w).
Fernandez Maria I. F.
Hotten Terrence M.
Tupper David E.
Chang Celia
Conrad Robert A.
Lilly Industries Limited
Lilly S.A.
Waddell Frederick E.
LandOfFree
Organic compounds and their use as pharmaceuticals does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Organic compounds and their use as pharmaceuticals, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Organic compounds and their use as pharmaceuticals will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1648652