Organic compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C544S090000, C544S105000

Reexamination Certificate

active

07842688

ABSTRACT:
Novel substituted piperidines of the general formulae (I) and (II)with the substituent definitions as explained in detail in the description are described. The compounds are suitable in particular as renin inhibitors and are highly potent.

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International Search Report issued on Mar. 1, 2005 in the International (PCT) Application PCT/EP2004/052389, on which the parent application of the present divisional application is based.
Eric Vieira et al., “Substituted Piperidines—Highly Potent Renin Inhibitors Due to Induced Fit Adaptation of the Active Site”, Bioorganic & Medicinal Chemistry Letters, vol. 9, pp. 1397-1402, XP002317176, 1999.
Rolf Güller et al., “Piperidine-Renin Inhibitors Compounds with Improved Physicochemical Properties”, Bioorganic & Medicinal Chemistry Letters, ISSN: 0960-894X, vol. 9, No. 10, pp. 1403-1408, XP002317171, 1999.
H.P. Märki et al., “Piperidine renin inhibitors: from leads to drug candidates”, Farmaco, 56(1-2) ISSN: 0014-827X, pp. 21-27, XP002317172, 2001.
Daiga M. Helmeste et al., “Serotonin uptake inhibitors modulate intracellular Ca2+ mobilization in platelets”, European Journal of Pharmacology, vol. 288, pp. 373-377, XP002317173, 1995.
Matthew G. Bursavich et al., “From Peptides to Non-Peptide Peptidomimetics: Design and Synthesis of New Piperidine Inhibitors of Aspartic Peptidases”, Organic Letters, vol. 3, No. 15, pp. 2317-2320, XP002317174, 2001.
Matthew G. Bursavich et al., “Solid-Phase Synthesis of Aspartic Peptidase Inhibitors: 3-Alkoxy-4-Aryl Piperidines”, Organic Letters, vol. 3, No. 17, pp. 2625-2628, XP002317175, 2001.

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