Oral pharmaceutical composition containing cyclosporin and proce

Details Oral pharmaceutical composition containing cyclosporin and proce Oral pharmaceutical composition containing cyclosporin and proce

1993-05-20

1995-07-04

Warden, Jill

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 11, A61K 3700, A61K 3174, A61K 3800

Patent

active

054300177

ABSTRACT:
The invention relates to a pharmaceutical composition for oral administration containing cyclosporin A and/or cyclosporin G as active ingredient, which possess advantageous absorption characteristics, and to a process for preparing this composition. The composition according to the invention comprises 1 part by mass of one or more cyclosporin(s) dissolved in 4 to 50 parts by volume of propylene glycol, 0 to 25 parts by volume of ethanol and 0.0 to 5 parts by mass of a polyoxyethylene/polyoxypropylene block polymer in homogenized state. Based on examinations carried out at 100.degree. C., the stability of solutions prepared according to the invention does not differ from that of the commercially available Sandimmun oral solution.

REFERENCES:
patent: 4649047 (1987-03-01), Kagwari
patent: 4996193 (1991-02-01), Hewitt et al.
patent: 5051402 (1991-09-01), Kurihara et al.

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