Optical detection in bio-separation device using axial...

Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory... – Means for analyzing liquid or solid sample

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C422S082060, C435S288600, C435S288700, C436S517000, C436S164000, C204S451000, C204S452000

Reexamination Certificate

active

06929779

ABSTRACT:
In a bio-separation system, emitted radiation signals representative of sample analytes are collected from the detection zone axially along the separation medium, instead of through the boundary walls of the detection zone or the separation column. In one embodiment, emitted signals are collected via an optic fiber that extends from the proximity of the detection zone along the detection collar. According to another embodiment, a single dual purpose (excitation and emission) fiber or dual fibers (one for excitation radiation and the other for emitted radiation detection) are incorporated into detection collar. In another aspect of the present invention, the detection zone is located at a widened zone along the separation channel. In a further aspect of the present invention, the optical detection configuration may be scaled up and implemented in a multi-channel CE system that comprises multiple capillary separation channels.

REFERENCES:
patent: 5062942 (1991-11-01), Kambara et al.
patent: 5198091 (1993-03-01), Burolla et al.
patent: 5324401 (1994-06-01), Yeung et al.
patent: 5338427 (1994-08-01), Shartle et al.
patent: 5366608 (1994-11-01), Kambara
patent: 5413686 (1995-05-01), Klein et al.
patent: 5439578 (1995-08-01), Dovichi et al.
patent: 5444807 (1995-08-01), Liu
patent: 5498324 (1996-03-01), Yeung et al.
patent: 5529679 (1996-06-01), Takahashi et al.
patent: 5543018 (1996-08-01), Stevens et al.
patent: 5545901 (1996-08-01), Pentoney, Jr. et al.
patent: 5560811 (1996-10-01), Briggs et al.
patent: 5584982 (1996-12-01), Dovichi et al.
patent: 5625403 (1997-04-01), Hazman et al.
patent: 5650846 (1997-07-01), Yin et al.
patent: 5741411 (1998-04-01), Yeung et al.
patent: 5741412 (1998-04-01), Dovichi et al.
patent: 5763277 (1998-06-01), Zhu et al.
patent: 5790727 (1998-08-01), Dhadwal et al.
patent: 5846727 (1998-12-01), Soper et al.
patent: 5968331 (1999-10-01), Kambara et al.
patent: 6001230 (1999-12-01), Burolla
patent: 6027627 (2000-02-01), Li et al.
patent: 6043880 (2000-03-01), Andrews et al.
patent: 6054032 (2000-04-01), Haddad et al.
patent: 6063251 (2000-05-01), Kane et al.
patent: 6084667 (2000-07-01), Melman et al.
patent: 6104485 (2000-08-01), Wang et al.
patent: 6132578 (2000-10-01), Kambara et al.
patent: 6153437 (2000-11-01), Horn
patent: 6184990 (2001-02-01), Amirkhanian et al.
patent: 6326213 (2001-12-01), Letcher et al.
patent: 0386925 (1990-09-01), None
patent: 0704699 (1996-04-01), None
Taylor et al, Axial-Beam Laser-Excited Fluorescence Detection In Capillary Electrohoresis, Anal. Chem 1992, 64, 1741-1744.
Tayler et al, Multiplexed Fluorescence Detector for Capillary Electrophoresis Using Axial Optical Fiber Illumination, Anal. Chem. 1993, vol. 65, 956-960.
Simultaneous Monitoring of DNA Fragments Separated by Electrophoresis in a Multiplexed Array of 100 Capillaries.
DNA Analysis Tools Shrink.
An Integrated Nanoliter DNA Analysis Device.
DNA Sequencing Using Capillary Array Electrophoresis.
Three DNA Sequencing Methods Using Capillary Gel Electrophoresis and Laser-Induced Fluorescence.
DNA Sequencing by Multiple Capillaries that Form a Waveguide.
A Capillary Array Gel Electrophoresis System Using Multiple Laser Focusing for DNA Sequencing.
Researchers Design DNA Lab on a Chip.
Laser-Induced Fluorescence Detection of a Single Molecule in a Capillary.
Up to Speed on PCR.
Low-Cost, High-Sensitivity Laser-Induced Fluorescence Detection for DNA Sequencing by Capillary Gel Electrophoresis.
Electrophoresis, 1996, 17, 1845-1851.
International Search Report of Counterpart PCT Application No. PCT/US02/20116.
Sepaniak, et al., “Demonstration of an Integrated Capillary Electrophoresis-Laser-Induced Fluorescence Fiber-Optic Sensor”, Talanta 43 (1996), pp. 1889-1901.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Optical detection in bio-separation device using axial... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Optical detection in bio-separation device using axial..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Optical detection in bio-separation device using axial... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3462897

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.