Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2005-08-16
2005-08-16
Davis, Minh-Tam (Department: 1642)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C530S827000, C424S009100, C514S002600
Reexamination Certificate
active
06930169
ABSTRACT:
The present invention describes a calcium-binding myristoylated protein with homology to calcineurin B which interacts preferentially with presenilin 2 protein. Also, the present invention relates to methods that alter protein-protein interaction of the calcium-binding myristoylated protein with presenilin 2 thereby reducing deleterious effects of the protein-protein interaction, such as apoptosis. The present invention further relates to introducing and expressing a mutant presenilin 2 protein or mutant calcium-binding myristoylated protein to modulate cell functions relating to calcium signaling and apoptosis.
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Pack-Chung, E., Myers, M.B., Pettingell, W.P., C
Monteiro Mervyn J.
Stabler Stacy
Davis Minh-Tam
Fuierer Marianne
Hultquist Steven
University of Baltimore Biotechnology Institute
Yang Yongzhi
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