Optical and electrical methods and apparatus for molecule detect

Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

422 681, 422 76, 422 8201, 422 8202, 422 8205, 422 912, 204456, 435 5, 435 6, 435 71, 435 79, 4352852, 436149, 436150, 436806, 436807, 530300, 530350, 530333, G01N 1506, G01N 2702, C07K 100

Patent

active

056539398

ABSTRACT:
A method and apparatus are disclosed for identifying molecular structures within a sample substance using a monolithic array of test sites formed on a substrate upon which the sample substance is applied. Each test site includes probes formed therein to bond with a predetermined target molecular structure or structures. A signal is applied to the test sites and certain electrical, mechanical and/or optical properties of the test sites are detected to determine which probes have bonded to an associated target molecular structure.

REFERENCES:
patent: 4054646 (1977-10-01), Giaever
patent: 4072576 (1978-02-01), Arwin
patent: 4238757 (1980-12-01), Schenck
patent: 4314821 (1982-02-01), Rice
patent: 4571543 (1986-02-01), Raymond et al.
patent: 4580895 (1986-04-01), Patel
patent: 4728882 (1988-03-01), Stanbro et al.
patent: 4760105 (1988-07-01), Fuller et al.
patent: 4769121 (1988-09-01), Newman
patent: 4777019 (1988-10-01), Dandekar
patent: 4816418 (1989-03-01), Mack et al.
patent: 4822566 (1989-04-01), Newman
patent: 4908112 (1990-03-01), Pace
patent: 4935207 (1990-06-01), Stanbro et al.
patent: 4938742 (1990-07-01), Smits
patent: 4963245 (1990-10-01), Weetall
patent: 5047213 (1991-09-01), Funlan et al.
patent: 5063081 (1991-11-01), Cozette et al.
patent: 5064754 (1991-11-01), Mills
patent: 5071733 (1991-12-01), Uekita et al.
patent: 5075077 (1991-12-01), Durley, IIi et al.
patent: 5082627 (1992-01-01), Stanbro et al.
patent: 5096807 (1992-03-01), Leaback
patent: 5143854 (1992-09-01), Pirruns et al.
patent: 5156810 (1992-10-01), Ribi et al.
patent: 5164319 (1992-11-01), Hafeman et al.
patent: 5187096 (1993-02-01), Giaever et al.
patent: 5194133 (1993-03-01), Clark et al.
patent: 5200051 (1993-04-01), Cozzette et al.
patent: 5202231 (1993-04-01), Drmanac et al.
patent: 5221605 (1993-06-01), Band et al.
patent: 5234566 (1993-08-01), Osman et al.
patent: 5298414 (1994-03-01), Bruce et al.
patent: 5310686 (1994-05-01), Sawyers et al.
patent: 5313264 (1994-05-01), Ivarsson et al.
patent: 5384261 (1995-01-01), Winkler et al.
Ekins et al., J. of Clinical Immunoassay, 13:169-181, 1996.
Pretty-Johns, et al., SPIE, 570:82-88, Aug. 22-23, 1985.
R.F. Taylor, Chap. 8, "Immobilized Antibody--and Receptor-Based Biosensors," Protein Immobilization--Fundamentals and Applications, ed R.F. Taylor, pp. 263-303 (1991).
S.P.A. Fodor, et al., "Light-Directed, Spatially Addressable Parallel Chemical Synthesis," Science, vol. 251, pp. 767-773 (Feb. 1991).
Gronow, Chap. 20: Biosensors--"A Marriage of Biochemistry and Microelectronics", Biotechnology, The Science & The Business, Moses, Cape, pp. 355-370 (1991).
Khrapko, et al., "An Oligonucleotide Hybridization Approach to DNA Sequencing", FEBS Letters vol. 256, No. 1,2:118-122 (1989).
Khrapko, et al., "A Method for DNA Sequencing by Hybridization with Oligonucleotide Matrix", in DNA Sequencing and Mapping, vol. 1:375-388 (1991).
Suzuki, et al., "A 1024-Element High-Performance Silicon Tactile Imager," IEEE IEDM 88, pp. 674-677 (1988).
Sugiyama, et al., "Micro-Diaphragm Pressure Sensor," IEEE, vol. 86 pp. 184-187 (1986).
Buser, et al., "Silicon Pressure Sensor Based on a Resonating Element," Sensors and Actuators A, vol. 25-27, pp. 717-722 (1991).
Prak, et al., "Q-Factor and Frequency Shift of Resonating Silicon Diaphragms in Air,"Sensors & Actuators A, vol. 25-27, pp. 691-698 (1991).
Craine, et al., "A Digital Optically Multiplexed Charge Coupled Device (CCD) Based Deoxyribonucleic Acid (DNA) Sequence Reader," Medical Imaging Ii, vol. 914, pp. 512-517 (1988).
Misiura, et al., "Biotinyl and Phosphotyrosinyl Phosphoramidite Derivatives Useful in the Incorporation of Multiple Reporter Groups on Synthetic Oligonucleotides,"Nucleic Acids Res., vol. 18, No. 15, pp. 4345-4354 (1990).
Kricka, "Chemiluminescent and Bioluminescent Techniques," Clinical Chemistry, vol. 37, No. 9, pp. 1472-1481 (1991).
Briggs, et al., "Sub-Femtomole Quantitation of Proteins with Threshold, for the Biopharmaceutical Industry," BioTechniques, vol. 9, No. 5, pp. 1-8 (1990).
Karger, et al., "Multiwavelength Fluorescence Detection for DNA Sequencing Using Capillary Electrophoresis," Nucleic Acids Res., vol. 19, No. 18, pp. 4955-4962 (1991).
Karger, et al., "Imaging of Fluorescent and Chemiluminescent DNA Hybrids Using a 2-D CCD Camera," New Technologies in Cytometry & Molecular Biology, vol. 1206, pp. 78-89 (1990).
Briggs, "Biosensors Emerge from the Laboratory," Nature, vol. 329, p. 565 (Oct. 1987).
Knight, et al., "Nonradioactive Nucleic Acid Detection by Enhanced Chemiluminescence Using Probes Directly Labeled with Horseradish Peroxidase," Analytical Biochemistry, vol. 185, pp. 84-89 (1990).
Hollis, et al., "A Swept-Frequency Magnitude Method for the Dielectric Characterization of Chemical and Biological Systems," IEEE Trans. on Microwave Theory and Techniques, vol. MIT-28, No. 7, pp. 791-801 (Jul. 1990).
Neff, et al., "Two-Dimensional Spatial Light Modulators: A Tutorial," Proceedings of the IEEE, vol. 78, No. 5 (1990).
Hornbeck, "Deformable-Mirror Spatial Light Modulators," SPIE Critical Reviews Series, vol. 1150, p. 86 (1990).
Grant, et al., "Dielectric Behavior of Biological Molecules in Solution," Clarendon, Pr., Oxford, pp. 2, 4, 217-220.
Hullidy, et al., Physics, New York, John Wiley & Sons, 1978, p. 658.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Optical and electrical methods and apparatus for molecule detect does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Optical and electrical methods and apparatus for molecule detect, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Optical and electrical methods and apparatus for molecule detect will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1072640

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.