Oncosuppressive gene

Details Oncosuppressive gene Oncosuppressive gene

2007-03-13

2007-03-13

Qian, Celine (Department: 1636)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S320100, C536S023100

Reexamination Certificate

active

10483241

ABSTRACT:
Isolation and characterization of an oncosuppressive gene which is involved in the apoptotic process and is regulated by p53 ad p73, polypeptide thereby encoded, sequences involved in gene regulation and genetic constructs thereof.

REFERENCES:
patent: WO 01 75067 (2001-10-01), None
patent: WO 02/28999 (2002-04-01), None
Nagase et al. Prediction of the Coding Sequences of Unidentified Human Genes. VI. The Coding Sequences of 80 New Genes (KIAA0201-KIAA0280) Deduced by Analysis of cDNA Clones from Cell Line KG-1 and Brain. DNA Research, vol. 3, pp. 321-329, 1996.
GenBank Accession No. D87434.1, Nov. 8, 1996.
Pietrzkowski et al. Characterization of an enhancer-like structure in the promoter region of the proliferating cell nuclear antigen (PCNA) gene. Exp Cell Res. vol. 193, No. 2, pp. 283-290, Apr. 1991.
Chan et al. Promoter analysis of the nuclear gene encoding the chloroplast glyceraldehyde-3-phosphate dehydrogenase B subunit ofArabidopsis thaliana. Plant Mol Biol. vol. 46, No. 2, pp. 131-141, May 2001.
El-Deiry et al. Definition of a consensus binding site for p53. Nat Genet. vol. 1, No. 1, pp. 45-49, Apr. 1992.
Omilli et al. Sequences involved in initiation of simian virus 40 late transcription in the absence of T antigen. Mol Cell Biol. vol. 6, No. 6, pp. 1875-1885, Jun. 1986.
GenBank Accession No. AL133445, GI: 13897486, publicly available Apr. 2001.
Database EMBL, Online, Feb. 13, 2002, Drmanac R.T., “DNA encoding human diagnostic protein #23497”, retrieved from EBI Database accession No. AAS87693 XP002232526.
Database EMBL, Online, Aug. 14, 2002, Beazer-Barclay et al., “Human cDNA differentially expressed in granulocytic cells #298”, retrieved from EBI Database accession No. ABK83727 XP002232527.
Database EMBL, Online, Jul. 2, 2001, Lee et al., “Human late stage ovarian tumour polynucleotide marker 8”, retrieved from EBI Database accession No. AAF98711 XP002232528.
Database EMBL, Online, Nov. 9, 1996, Ohara et al., “Human mRNA for KIAA0247 gene”, Database accession No. D87434 XP002232529.
Database EMBL, Online,EBI, EST, Organ: mammary, tissue: tumor biopsy sample, Feb. 15, 2000, Strausberg R.: “Mus musculus cDNA clone Image: 2648685 5', mRNA”, Database accession No. AW412392 XP002243000.
Database EMBL, Online, EBI, Feb. 2, 2001, Rosen, C.A., “Human secreted protein cDNA #6”, Database accession No. AAC59340 XP002243001.
Funk et al., “A transcriptionally active DNA-binding site for human P53 protein complexes”, Molecular and Cellular Biology, Washington, DC, vol. 12, No. 6, Jun. 1, 1992, pp. 2866-2871, XP000676472.
De Laurenzi et al., “Evolution of functions within the p53/p63/p73 family” Annals of the New York Academy of Sciences, vol. 926, Dec. 2000, pp. 90-100 XP009011712.
Ng Shu-Wing et al., “Analysis of p73 in human borderline and invasive ovarian tumor”, Oncogene, vol. 19, No. 15, Apr. 6, 2000, pp. 1885-1890 XP009011716.
Pestell et al., “Characterisation of the P53 status, BCL-2 expression and radiation . . . ”, International Journal of Cancer, vol. 77, No. 6, pp. 913-918 XP002242999.

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