Drug – bio-affecting and body treating compositions – Lymphokine – Interferon
Patent
1987-05-04
1992-06-09
Weimar, Elizabeth C.
Drug, bio-affecting and body treating compositions
Lymphokine
Interferon
424 851, 424 854, 514 2, 514 21, 4352402, 4352403, A61K 3702, A61K 3766, A61K 4505
Patent
active
051205351
ABSTRACT:
Novel compositions are provided for modulating growth, particularly of tumor cells, which compositions are combinations of Oncostatin M, and one or both of transforming growth factors or .gamma.-interferons, or analogs thereof. In addition, a novel transforming growth factor is provided, designated TGF-.beta.2, as well as methods for its preparation.
REFERENCES:
patent: 4737580 (1988-04-01), Twardzik et al.
Lee et al., J. of Imm. 133:3, 1083-1086, 1984, "The Synergistic Proliferative Effect of Interferon & Human Lumpotoxin".
Amento et al., PNAS, 79: 5307-5311, 1982, "Modulation of synovial cell products by a factor from a human cell line T lymphocyte induction of a mononuclear cell factor".
Aggawal et al., JBC 259, 686-691, 1984, Human Lymphotoxin.
Sporn et al., NEJM, Oct. 1980, 878-880, "Autocrine Secretion and Malignant Transformation of Cells".
Ciba Foundation Symposium 116, Burgess, "Medical Aspects of Growth Factors", p. 261, Ciba Foundation, Oct. 1985.
Larry Ellingsworth et al., Journal of Biological Chemistry, "Anti-Bodies to the N-Terminal Portion of Cartilage-Inducing Factor A & Transforming Growth Factor-.beta." (1986) 261: 12362-12367.
Saeid Seyedin et al., Proc. Natl. Acad. Sci. U.S.A., "Purification and characterization of two cartilage-inducing factors from bovine demineralized bone", (1985) 82: 2267-2271.
Saeid Seyedin et al., J. Biol. Chem., "Cartilage-Inducing Factor-.beta. is a Unique Protein Structurally and Functionally Related to Transforming Growth Factor-.beta.", (1987) 260: 1946-1949.
Brown Thomas J.
Hanson Marcia B.
Ikeda Tatsuhiko
Lioubin Mario N.
Marquardt Hans
Oncogen
Poulos Gail
Weimar Elizabeth C.
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