Oligonucleotides for modulating the effects of cytomegalovirus i

Details Oligonucleotides for modulating the effects of cytomegalovirus i Oligonucleotides for modulating the effects of cytomegalovirus i

1993-01-25

1995-08-15

Zitomer, Stephanie W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C07H 2104, A61K 4800

Patent

active

054420490

ABSTRACT:
Compositions and methods for modulating the effects of cytomegalovirus (CMV) infections are disclosed, comprising contacting CMV mRNA with an oligonucleotide which can bind with at least portions of the CMV RNA. In accordance with the preferred embodiments, oligonucleotides such as ISIS 2922 are designed to bind with portions of the CMV mRNAs which code for the IE1, IE2 or DNA polymerase proteins. In accordance with a preferred embodiment, methods of treatment of human cytomegalovirus are disclosed.

REFERENCES:
patent: 5034506 (1991-07-01), Summerton et al.
Kouzarides et al., J. Virol. 61 V.):125-133 (Jan. 1987).
Ratner, Bio/Technology 7:207 (Mar. 1989).
Stenberg et al., J. Virol. 49 V.):190-199 (Jan. 1984). ibid. 56(3):665-675 (Dec. 1985).
Stein et al., Science 261:1004-1112 (20 Aug. 1993).
Cohen, Jack S., Oligodeoxynucleotides: Antisense Inhibitors of Gene Expression, CRC Press: Boca Raton, Fla., 1989.
P. S. Miller & P.O.P. Ts'O, "A new approach to chemotherapy based on molecular biology and nucleic acid chemistry: Matagen (masking tape for gene expression)," Anti-Cancer Drug Design 1987, 2:117-128.
Nielsen, Peter E., et al., "Sequence--Selective Recognition of DNA by Strand Displacement with a Tyymine--Substituted Polyamide," Science, 254:1497-1500, 1991.
Rothenberg et al., "Oligodeoxynucleotides as Anti-Sense Inhibitors of Gene Expression: Therapeutic Implicaitons," J. Natl. Cancer Inst., 81:1539-1544, 1989.
Zon, G. "Oligonucleotides Analogues as Potential Chemotherapeutic Agents," Pharmaceutical Res., 5:539-549, 1988.

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