Oligonucleotide-linked magnetic particles and uses thereof

Details Oligonucleotide-linked magnetic particles and uses thereof Oligonucleotide-linked magnetic particles and uses thereof

1994-07-06

1996-04-30

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 911, 435 912, 435 915, 514 44, 436526, C12P 1934, C12Q 168, G01N 33553

Patent

active

055124399

ABSTRACT:
Monodisperse, superparamagnetic particles carrying a plurality of molecules of an oligonucleotide are disclosed and may be used inter alia for sequencing single-stranded nucleic acids. The oligonucleotide may be covalently attached or affinity bonded to the particles either by their 3' or 5' termini. The particles have a specific gravity in the range 1.1-1.8 and are 1-10 microns in diameter. A kit for the isolation or processing of target nucleic acid is also disclosed.

REFERENCES:
patent: 4654267 (1992-03-01), Ugelstad et al.
patent: 4672040 (1987-06-01), Josephson
patent: 4774265 (1988-09-01), Ugelstad et al.
patent: 4775619 (1988-10-01), Urdea
Matijevic, E. Acc. Chem. Res. 14:22-29 (1981).
Chu et al. DNA 4(4) 327-331, 1985.
Nucleic Acids Research, vol. 16, No. 13, 1988, p. 6232, Atkinson et al.
Nucleic Acids Research, vol. 16, No. 7, pp. 3025-3028, Apr. 11, 1988, Stefan Stahl et al.
Chemical Abstracts, vol. 108, 1988, Monograph No. 201021e, Ugelstad et al.

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