Octapeptide LHRH antagonists

Details Octapeptide LHRH antagonists Octapeptide LHRH antagonists

1990-07-10

1992-08-18

Cashion, Jr., Merrell C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 15, 530313, 530328, 530329, C07K 706, C07K 720, A61K 3738

Patent

active

051400090

ABSTRACT:
The present invention relates to novel LHRH analogs. The LHRH analogs include "pseudo" hexapeptide, heptapeptide, octapeptide and nonapeptide analogs of LHRH, wherein all or some of the amino acids, 1, 2 and 3 have been eliminated and the remaining (2-9), (2-10), (3-9), (3-10), (4-9) or (4-10) peptide is linked to various carboxylic acids which take the place of amino acids 1, 2 or 3 in LHRH.

REFERENCES:
patent: 4493934 (1985-01-01), Verber et al.
patent: 4690916 (1987-09-01), Nestor et al.
patent: 4760053 (1988-07-01), Labrie
Stewart, et al., Solid Phase Peptide Synthesis, Pierce Chem. Co., 1984.
Koch, et al., Chem. Abs., 107:33505z, p. 109, 1987.
Shidgel, R., et al., Proc. Natl. Acad. Sci., 82:1025-1029, 1985.
Wojciechowski, et al., Drug. Intell. and Clinical Pharmacy, 20:746-751, 1986.
Furr, et al., J. Endocrinol. Invest., 11:535-557, 1988.
Burov, et al., Chem. Abstracts 108:16411 (1988).
Sandow, et al., J. Endocrinol. 81 175 (1979).
Cyril Y. Bowers, "LH and FSH Release," in Biol. Act. Princ. Nat. Prod. Wolfgang Voelker, Daves, Doyle & G. Thieme, Stuttgart, Germany, 1984, pp. 126-137.

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