Octahydronaphthoquinolizines, and methods of making and using th

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

546 71, C07D21516, A61K 3147

Patent

active

052985091

ABSTRACT:
Stereoisomeric substituted and/or unsubstituted octahydronaphthoquinolizines (OHNQs), and derivatives and analogs thereof are provided, including pharmaceutical and diagnostic compositions, as well as methods of making and using these compounds according to the following formula I: ##STR1##

REFERENCES:
patent: 1176597 (1916-03-01), Pictet
patent: 3933826 (1976-01-01), Kametami
patent: 4128650 (1978-12-01), Fabre et al.
Mandell, Leon et al., "The Synthesis of Tricyclic Systems with Nitrogen at a Bridgehead," J. Org. Chem., vol. 28, pp. 3440-3442, (1963).
Mandell, Leon et al., "A Conveniant Synthesis of Tricyclic 2-Quinolizidones," Journal of Org. Chem., vol. 29, pp. 3067-6812, (1964).
Bowen, Wayne D. et al., "Metabolites of haloperidol display preferential activity at o receptors compared compared to dopamine D-2 receptors," European Journal of Pharmacology, vol. 177, pp. 111-118, (1990).
Gundlach, Andrew L. et al., "Phencycline and o Opiate Receptors in Brain: Biochemical and Autoradiographical Differentiation," European Journal of Pharmacology, vol. 113, pp. 465-466, (1985).
Wikstrom, Hakan et al., "N-Substituted 1,2,3,4,4a,5,6,10b-Octahydrobenzo[f]quinolines and 3-Phenylpiperidines: Effects on Central Dopamine and o Receptors," J. Med. Chem., vol. 30, pp. 2169-2174, (1987).
Van de Waterbeemd, Han et al., "Quantative Structure-Activity Relationships and Eudismic Analyses of the Presynaptic Dopaminergic Activity and Dopamine D2 and o Receptor Affinities of 3-(3-Hydroxyphenyl) piperidines and Octahydrobenzo[f]quinolines," J. Med. Chem., vol. 30, pp. 1275-2181, (1987).
Gundlach, Andrew L. et al., "Autoradiographic Localization of Sigma Receptor binding sites in Guinea Pig and Rat Central Nervous System with (+).sup.3 H-3-(3-Hydroxyphenyl)-N.varies.(1-propyl)piperidine," The Journal of Neuroscience, vol. 6, No. 6, pp. 1757-1770, (1986).
Mandell, Leon et al., "The Total Synthesis of d,l-Matrine and d,l-Leontine," Journal of the American Chemical Society, vol. 87, No. 22, pp. 5234-5236, (1965).
Largent, Brian L. et al., "Structural Determinants of o Receptor Affinity," Molecular Pharmacology, vol. 32, pp. 772-784, (1987).
Su, Tsung-Ping et al., "Endogenous Ligands for Sigma Opioid Receptors in the Brain(Sigmaphin): Evidence From Binding Assays," Life Sciences, vol. 38, pp. 2199-2210, (1986).
Itzhak, Yossef et al., "Characterization of n-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Binding Sites in C57BL/6 Mouse Brain: Mutual Effects of Monoamine Oxidase Inhibitors and o Ligands on MPTP and o binding sites," Molecular Pharmacology, vol. 39, pp. 385-393, (1990).
Largent, Brian L. et al., "Psychotomimetic opiate receptors labeled and visualized with (+)-[.sup.3 H]3-(3-hydroxypheny)-N-(1-propyl)piperidine," Proc. Natl. Acad. Sci. USA, vol. 81, pp. 4983-4987, (1984).
Largent, Brian L. et al., "Novel antipsychotic drugs share high affinity for a o receptors," European Journal of Pharmacology, vol. 155, pp. 345-347, (1988).
Tam, S. William et al., "o opiates and certain antipsychotic drugs mutually inhibit (+)-[.sup.3 H]SKF 10,047 and [.sup.3 H]haloperidol binding in guinea pig brain membranes," Neurobiology, vol. 81, pp. 5618-5621, (1984).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Octahydronaphthoquinolizines, and methods of making and using th does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Octahydronaphthoquinolizines, and methods of making and using th, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Octahydronaphthoquinolizines, and methods of making and using th will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-792051

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.