O-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkyn

Details O-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkyn O-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkyn

1993-10-12

1994-09-20

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

A61K 31345, C07D49116

Patent

active

053490614

ABSTRACT:
O-Heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroaryl-macrolides of the general structural Formula I: ##STR1## have been prepared from suitable precursors by alkylation and/or arylation at C-3" and/or C-4" of the cyclohexyl ring. These macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases, the prevention of rejection of foreign organ transplants and/or related afflictions, diseases and illnesses.

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patent: 5252732 (1993-10-01), Sinclair et al.
patent: 5262533 (1993-11-01), Sinclair et al.

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