Rapamycin 31-ester with N,N-dimethylglycine derivatives useful a

Details Rapamycin 31-ester with N,N-dimethylglycine derivatives useful a Rapamycin 31-ester with N,N-dimethylglycine derivatives useful a

1993-05-06

1994-09-20

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

514291, C07D49116, A61K 31395

Patent

active

053490606

ABSTRACT:
A derivative of rapamycin of general formula (1) and (2) ##STR1## wherein ##STR2## or hydrogen; R.sup.2 =hydrogen, or lower alkyl having 1 to 6 carbon atoms; ##STR3## wherein X=hydrogen, lower alkyl having 1 to 6 carbon atoms, --CF.sub.3, --NO.sub.2, --OR.sup.2, NR.sup.2, SR.sup.2, or halogen; R.sup.4 =lower alkyl, alkenyl or alkynyl having 1 to 6 carbon atoms or an aromatic or heterocyclic moiety selected from the group consisting of phenyl, naphthyl, thiophenyl and quinolinyl;

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