Nucleoside analogues and oligonucleotide derivative...

Details Nucleoside analogues and oligonucleotide derivative... Nucleoside analogues and oligonucleotide derivative...

2003-02-13

2009-11-10

Crane, Lawrence E (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S024500, C536S026700, C536S026800, C536S027100

Reexamination Certificate

active

07615619

ABSTRACT:
A nucleotide analogue compound represented by formula (1) and salts thereof. In formula (1), A represents a direct bond, C1-4alkylene, etc.; B represents an optionally substituted aromatic heterocyclic groups; and R1, R2, R3and R4each represents hydrogen, an amino-protecting group, a hydroxyl-protecting group, a phosphate group, or —P(R7)R8, wherein R7and R8each represents hydroxyl, protected hydroxyl, mercapto, protected mercapto, etc. The compounds are useful as nucleotide analogues for producing oligonucleotide analogues useful in an antisense method and for producing intermediates thereof.

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