Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2008-09-22
2009-12-01
Gambel, Phillip (Department: 1644)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S023100, C536S023500, C435S069600, C435S252300, C435S320100, C435S326000, C435S328000, C435S332000, C435S334000, C435S343000, C435S343100, C435S455000
Reexamination Certificate
active
07626012
ABSTRACT:
The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to CD40, preferably human CD40, and that function as CD40 agonists. The invention also relates to human anti-CD40 antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-CD40 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-CD40 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-CD40 antibodies. The invention also relates to transgenic animals comprising nucleic acid molecules of the present invention.
REFERENCES:
patent: 4399216 (1983-08-01), Axel et al.
patent: 4510245 (1985-04-01), Cousens et al.
patent: 4634665 (1987-01-01), Axel et al.
patent: 4735210 (1988-04-01), Goldenberg
patent: 4740461 (1988-04-01), Kaufman
patent: 4912040 (1990-03-01), Kaufman et al.
patent: 4959455 (1990-09-01), Clark et al.
patent: 4968615 (1990-11-01), Koszinowski et al.
patent: 5151510 (1992-09-01), Stec et al.
patent: 5168062 (1992-12-01), Stinski
patent: 5179017 (1993-01-01), Axel et al.
patent: 5223409 (1993-06-01), Ladner et al.
patent: 5545806 (1996-08-01), Lonberg et al.
patent: 5545807 (1996-08-01), Surani et al.
patent: 5569825 (1996-10-01), Lonberg
patent: 5587458 (1996-12-01), King et al.
patent: 5591669 (1997-01-01), Krimpenfort et al.
patent: 5612205 (1997-03-01), Kay et al.
patent: 5625126 (1997-04-01), Lonberg et al.
patent: 5633425 (1997-05-01), Lonberg et al.
patent: 5643763 (1997-07-01), Dunn et al.
patent: 5661016 (1997-08-01), Lonberg et al.
patent: 5677165 (1997-10-01), De Boer et al.
patent: 5721367 (1998-02-01), Kay et al.
patent: 5741957 (1998-04-01), Deboer et al.
patent: 5747498 (1998-05-01), Schnur et al.
patent: 5750172 (1998-05-01), Meade et al.
patent: 5756687 (1998-05-01), Denman et al.
patent: 5770429 (1998-06-01), Lonberg et al.
patent: 5789215 (1998-08-01), Berns et al.
patent: 5789650 (1998-08-01), Lonberg et al.
patent: 5792783 (1998-08-01), Tang et al.
patent: 5814318 (1998-09-01), Lonberg et al.
patent: 5827690 (1998-10-01), Meade et al.
patent: 5834504 (1998-11-01), Tang et al.
patent: 5861510 (1999-01-01), Piscopio et al.
patent: 5863949 (1999-01-01), Robinson et al.
patent: 5874082 (1999-02-01), De Boer
patent: 5877305 (1999-03-01), Huston et al.
patent: 5883113 (1999-03-01), Tang et al.
patent: 5886020 (1999-03-01), Tang et al.
patent: 5916771 (1999-06-01), Hori et al.
patent: 5939598 (1999-08-01), Kucherlapati et al.
patent: 5959177 (1999-09-01), Hein et al.
patent: 5985615 (1999-11-01), Jakobovits et al.
patent: 5994619 (1999-11-01), Stice et al.
patent: 5998209 (1999-12-01), Jokobovits et al.
patent: 6046037 (2000-04-01), Hiatt et al.
patent: 6051228 (2000-04-01), Aruffo et al.
patent: 6075181 (2000-06-01), Kucherlapati et al.
patent: 6091001 (2000-07-01), Jakobovits et al.
patent: 6114598 (2000-09-01), Kucherlapati et al.
patent: 6130364 (2000-10-01), Jakobovits et al.
patent: 6150584 (2000-11-01), Kucherlapati et al.
patent: 6162963 (2000-12-01), Kucherlapati et al.
patent: 6312693 (2001-11-01), Aruffo et al.
patent: 6417429 (2002-07-01), Hein et al.
patent: 6440418 (2002-08-01), Black et al.
patent: 6482411 (2002-11-01), Ahuja et al.
patent: 6517529 (2003-02-01), Quinn et al.
patent: 6713610 (2004-03-01), Kucherlapati et al.
patent: 6843989 (2005-01-01), Siegall et al.
patent: 7288251 (2007-10-01), Bedian et al.
patent: 7338660 (2008-03-01), Bedian et al.
patent: 2001/0026932 (2001-10-01), Thomas et al.
patent: 2002/0142358 (2002-10-01), Mikayama et al.
patent: 2003/0059427 (2003-03-01), Force et al.
patent: 2003/0118588 (2003-06-01), Diehl et al.
patent: 0 216 846 (1987-04-01), None
patent: 0 256 055 (1988-02-01), None
patent: 0 323 997 (1989-07-01), None
patent: 0 338 841 (1989-10-01), None
patent: 0 606 046 (1994-07-01), None
patent: 0 780 386 (1997-06-01), None
patent: 0 818 442 (1998-01-01), None
patent: 0 931 788 (1999-07-01), None
patent: 0 945 864 (1999-09-01), None
patent: 1 004 578 (2000-05-01), None
patent: 8012700 (1996-01-01), None
patent: 2000 124084 (2000-09-01), None
patent: 2000 109255 (2002-01-01), None
patent: WO 90/05719 (1990-05-01), None
patent: WO 91/10741 (1991-07-01), None
patent: WO 91/17271 (1991-11-01), None
patent: WO 92/01047 (1992-01-01), None
patent: WO 92/09690 (1992-06-01), None
patent: WO 92/15679 (1992-09-01), None
patent: WO 92/18619 (1992-10-01), None
patent: WO 92/20791 (1992-11-01), None
patent: WO 93/01288 (1993-01-01), None
patent: WO 93/06213 (1993-04-01), None
patent: WO 94/02602 (1994-02-01), None
patent: WO 95/09653 (1995-04-01), None
patent: WO 95/17202 (1995-06-01), None
patent: WO 95/19970 (1995-07-01), None
patent: WO 95/21613 (1995-08-01), None
patent: WO 96/18413 (1996-06-01), None
patent: WO 96/27583 (1996-09-01), None
patent: WO 96/33172 (1996-10-01), None
patent: WO 96/33735 (1996-10-01), None
patent: WO 96/34096 (1996-10-01), None
patent: WO 97/13760 (1997-04-01), None
patent: WO 97/22596 (1997-06-01), None
patent: WO 97/32856 (1997-09-01), None
patent: WO 98/02434 (1998-01-01), None
patent: WO 98/02437 (1998-01-01), None
patent: WO 98/02438 (1998-01-01), None
patent: WO 98/03516 (1998-01-01), None
patent: WO 98/07697 (1998-02-01), None
patent: WO 98/14451 (1998-04-01), None
patent: WO 98/16654 (1998-04-01), None
patent: WO 98/24893 (1998-06-01), None
patent: WO 98/30566 (1998-07-01), None
patent: WO 98/33768 (1998-08-01), None
patent: WO 98/34915 (1998-08-01), None
patent: WO 98/34918 (1998-08-01), None
patent: WO 98/50356 (1998-11-01), None
patent: WO 98/50433 (1998-11-01), None
patent: WO 98/52976 (1998-11-01), None
patent: WO 98/54093 (1998-12-01), None
patent: WO 99/07675 (1999-02-01), None
patent: WO 99/10349 (1999-03-01), None
patent: WO 99/16755 (1999-04-01), None
patent: WO 99/24440 (1999-05-01), None
patent: WO 99/29667 (1999-06-01), None
patent: WO 99/35132 (1999-07-01), None
patent: WO 99/35146 (1999-07-01), None
patent: WO 99/45031 (1999-09-01), None
patent: WO 99/52889 (1999-10-01), None
patent: WO 99/52910 (1999-10-01), None
patent: WO 99/53049 (1999-10-01), None
patent: WO 99/61057 (1999-12-01), None
patent: WO 99/61422 (1999-12-01), None
patent: WO 99/62890 (1999-12-01), None
patent: WO 00/09560 (2000-02-01), None
patent: WO 00/34317 (2000-05-01), None
patent: WO 00/37504 (2000-06-01), None
patent: WO 00/66155 (2000-11-01), None
patent: WO 01/37870 (2001-05-01), None
patent: WO 01/56603 (2001-08-01), None
patent: WO 01/83755 (2001-11-01), None
patent: WO 02/88186 (2002-11-01), None
Albert et al., “Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLS,”Nature, 392:86-89 (1998).
Alderson et al., “CD40 expression by human monocytes: regulation by cytokines and activation of monocytes by the ligand for CD40,”The Journal of Experimental Medicine, 178:669-674 (1993).
Alexandroff et al., “Role for CD40-CD40 ligand interactions in the immune response to solid tumours.”Molecular Immunology37(9):515-526 (2000).
Altenburg et al., “CD40 ligand-CD40 interaction induces chemokines in cervical carcinoma cells in synergism with IFN-γ,”The Journal of Immunology, 162:4140-4147 (1999).
Altschul et al., “Basic local alignment search tool,”Journal of Molecular Biology, 215(1):403-410 (1990).
Altschul et al., “Gapped BLAST and PSI-BLAST: a new generation of protein database search programs,”Nucleic Acids Research, 25(17):3389-402 (1997).
Armant et al., “Functional CD40 ligand expression on T lymphocytes in the absence of T cell receptor engagement: involvement in interleukin-2-induced interleukin-12 and inte
Bedian Vahe
Corvalan Jose
Feng Xiao
Gladue Ronald P.
Jia Xiao-Chi
Amgen Fremont Inc.
Gambel Phillip
Gunnison Jane T.
Li Z. Ying
Pfizer Inc.
LandOfFree
Nucleic acid molecules which encode antibodies that bind CD40 does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Nucleic acid molecules which encode antibodies that bind CD40, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acid molecules which encode antibodies that bind CD40 will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4071245