Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Reexamination Certificate
2004-08-31
2008-12-23
Kemmerer, Elizabeth C. (Department: 1646)
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
C435S325000, C435S254110, C435S320100, C536S023100, C536S023500
Reexamination Certificate
active
07468268
ABSTRACT:
A protein which inhibits osteoclast differentiation and/or maturation and a method for producing the protein. The protein is produced by human embryonic lung fibroblasts and has a molecular weight of about 60 kD and about 120 kD under non-reducing conditions and about 60 kD under reducing conditions on SDS-polyacrylamide gel electrophoresis. The protein can be isolated and purified from the culture medium of fibroblasts. Furthermore, the protein can be produced by gene engineering. The present invention includes cDNA for producing the protein by gene engineering, antibodies having specific affinity for the protein or a method for determining protein concentration using these antibodies.
REFERENCES:
patent: 4179337 (1979-12-01), Davis et al.
patent: 4710473 (1987-12-01), Morris
patent: 4959314 (1990-09-01), Mark et al.
patent: 5118667 (1992-06-01), Adams et al.
patent: 5266683 (1993-11-01), Oppermann et al.
patent: 5366859 (1994-11-01), Miyoshi et al.
patent: 5374529 (1994-12-01), Caterson et al.
patent: 5393739 (1995-02-01), Bentz et al.
patent: 5427954 (1995-06-01), Sandy et al.
patent: 5447851 (1995-09-01), Beutler et al.
patent: 5457035 (1995-10-01), Baum et al.
patent: 5545722 (1996-08-01), Naka
patent: 5578569 (1996-11-01), Tam
patent: 5585479 (1996-12-01), Hoke et al.
patent: 5599708 (1997-02-01), Mundy et al.
patent: 5658756 (1997-08-01), Rodan et al.
patent: 5736506 (1998-04-01), Naka
patent: 5830850 (1998-11-01), Gelb et al.
patent: 5843678 (1998-12-01), Boyle
patent: 5843901 (1998-12-01), Roeske
patent: 5985832 (1999-11-01), Roodman et al.
patent: 6015938 (2000-01-01), Boyle et al.
patent: 6017729 (2000-01-01), Anderson et al.
patent: 6046033 (2000-04-01), Goto et al.
patent: 6087555 (2000-07-01), Dunstan et al.
patent: 6242213 (2001-06-01), Anderson
patent: 6242586 (2001-06-01), Gorman et al.
patent: 6271349 (2001-08-01), Dougall et al.
patent: 6284485 (2001-09-01), Boyle et al.
patent: 6284728 (2001-09-01), Boyle et al.
patent: 6284740 (2001-09-01), Boyle et al.
patent: 6288032 (2001-09-01), Boyle et al.
patent: 6297022 (2001-10-01), McDonnell et al.
patent: 6316408 (2001-11-01), Boyle
patent: 6369027 (2002-04-01), Boyle et al.
patent: 6419929 (2002-07-01), Anderson
patent: 6479635 (2002-11-01), Anderson et al.
patent: 6525180 (2003-02-01), Gorman et al.
patent: 6528482 (2003-03-01), Anderson et al.
patent: 6537763 (2003-03-01), Dougall et al.
patent: 6562948 (2003-05-01), Anderson
patent: 6613544 (2003-09-01), Boyle et al.
patent: 6649164 (2003-11-01), Maraskovsky
patent: 6693175 (2004-02-01), Yano et al.
patent: 6740522 (2004-05-01), Anderson
patent: 2002/0081720 (2002-06-01), Dougall et al.
patent: 2002/0086826 (2002-07-01), Anderson et al.
patent: 2002/0086827 (2002-07-01), Anderson et al.
patent: 2002/0127637 (2002-09-01), Ni et al.
patent: 2002/0150989 (2002-10-01), Greene et al.
patent: 2002/0169117 (2002-11-01), Maraskovsky
patent: 2003/0045456 (2003-03-01), Yamamoto et al.
patent: 2003/0100069 (2003-05-01), Ni et al.
patent: 2003/0100488 (2003-05-01), Boyle
patent: 2003/0103978 (2003-06-01), Deshpande et al.
patent: 2003/0104485 (2003-06-01), Boyle
patent: 2003/0139325 (2003-07-01), Yamamoto et al.
patent: 2003/0144480 (2003-07-01), Gorman et al.
patent: 2003/0166097 (2003-09-01), Greene et al.
patent: 2003/0175840 (2003-09-01), Anderson et al.
patent: 2003/0176647 (2003-09-01), Yamaguchi et al.
patent: 2003/0181418 (2003-09-01), Kumakura et al.
patent: 2003/0207827 (2003-11-01), Boyle et al.
patent: 2003/0208045 (2003-11-01), Yamaguchi et al.
patent: 2003/0216297 (2003-11-01), Kumakura et al.
patent: 2004/0033535 (2004-02-01), Boyle et al.
patent: 0514130 (1992-11-01), None
patent: 0514130 (1992-11-01), None
patent: 0526905 (1993-02-01), None
patent: 0526905 (1993-02-01), None
patent: 0727211 (1996-08-01), None
patent: 0 784 093 (1997-07-01), None
patent: 0874045 (1998-10-01), None
patent: 0911342 (1999-04-01), None
patent: 0 974 671 (2000-01-01), None
patent: 1 127 578 (2001-08-01), None
patent: 1 270 015 (2003-01-01), None
patent: 1 270 015 (2004-02-01), None
patent: 62-201825 (1987-09-01), None
patent: 330400 (1999-05-01), None
patent: 86/00922 (1986-02-01), None
patent: 90/14363 (1990-11-01), None
patent: 93/12227 (1993-06-01), None
patent: 93/21946 (1993-11-01), None
patent: 95/11308 (1995-04-01), None
patent: 96/28546 (1996-09-01), None
patent: 97/00317 (1997-01-01), None
patent: 97/00318 (1997-01-01), None
patent: 97/23614 (1997-07-01), None
patent: 98/07840 (1998-02-01), None
patent: 98/25958 (1998-06-01), None
patent: 98/28424 (1998-07-01), None
patent: 98/28426 (1998-07-01), None
patent: 98/46211 (1998-10-01), None
patent: 98/46644 (1998-10-01), None
patent: 98/46751 (1998-10-01), None
patent: 98/49305 (1998-11-01), None
patent: 99/15691 (1999-04-01), None
patent: 99/19468 (1999-04-01), None
patent: 99/53942 (1999-10-01), None
patent: 99/58674 (1999-11-01), None
patent: 99/58674 (1999-11-01), None
patent: 01/03719 (2001-01-01), None
patent: 01/03719 (2001-01-01), None
patent: 01/17543 (2001-03-01), None
patent: 01/17543 (2001-03-01), None
patent: 01/18203 (2001-03-01), None
patent: 01/44472 (2001-06-01), None
patent: 03/002713 (2003-01-01), None
patent: 03/074084 (2003-09-01), None
Langdahl et al., J Bone Miner Res. Jul. 2002;17(7):1245-55.
Daroszewska et al., J Bone Miner Res. Sep. 2004; 19:1506-11.
Zubler RH; Swiss Med Wkly. Dec. 23, 2006;136(49-50):795-9.
Phillips, A., J Pharm Pharmacology 53: 1169-1174, 2001.
Lewis et al. Proc Natl Acad Sci. USA. 1991;88: 2830-2834.
Principles of nucleic acid hybridization, downloaded on Dec. 15, 2007 from ncbi.nlm.nih.gov/books/bv.fcgi?rid=hmg.section.484; 4 pages.
Jean-Jacques Body, “Current and Future Directions in Medical Therapy: Hypercalcemia,”Cancer Supplement, 88(12):3054-3058 (2000).
Chemical Abstracts, vol. 123, No. 18, Abstract No. 237583p (1995).
Chowdhury et al., “Effects of Heparin on Osteoclast Activity,”Journal of Bone and Mineral Research, 7(7):771-777 (1992).
Cochran and Abernathy, “Modulation of Bone Resorption by Glycosaminoglycans: Effects of Parathyroid Hormone and Interleukin-1,”Bone, 9(5):331-335 (1988).
Fautrel and Guillemin, “Cost of illness studies in rheumatic diseases,”Current Opinion in Rheumatology, 14:121-126 (2002).
Green et al., “Renal Tolerability Profile of Novel, Potent Bisphosphonates in Two Short-Term Rat Models,”Pharmacology&Toxicology, 80:225-230 (1997).
Iqbal and Sobhan, “Osteoporosis: A Review,”Missouri Medicine, 99(1):19-24 (2002).
Porcel et al., “Anaphylaxis to calcitonin,”Allergologia et immunopathologia, 28(4):243-245 (2000).
Romas et al., “Involvement of Receptor Activator of NFκB Ligand and Tumor Necrosis Factor-α in Bone Destruction in Rheumatoid Arthritis,”Bone, 30(2):340-346 (2002).
Tomoyasu et al., “Characterization of Monomeric and Homodimeric Forms of Osteoclastogenesis Inhibitory Factor,”Biochemical and Biophysical Research Communications, 245(2):382-387 (1998).
White and Schilling, “Postmenopausal Hormone Replacement: Historical Perspectives and Current Concerns,”Clinical Excellence for Nurse Practitioners, 4(5):277-285 (2000).
Yamamoto et al., “Hypocalcemic Effect of Osteoclastogenesis Inhibitory Factor/Osteoprotegerin in the Thyroparathyroidectomized Rat,”Endocrinology, 139(9):4012-4015 (1998).
Adams et al., “Complementary DNA Sequencing: Expressed Sequence Tags and Human Genome Project”,Science, 252:1651-1656 (1991).
Anderson et al., “A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function”,Nature, 390:175-179 (1997).
Banks et al., “Effect of degenerative spinal and aortic calcification on bone density measurements in post-menopausal women: links between osteoporosis and cardiovascular disease?”,European Journal of Clinical Investigation, 24(12):813-817 (1994).
Banner et al., “Crystal Structure of the Soluble Human 55 kd TNF Receptor-Human TNFβ Complex: Implications of TNF Receptor Acti
Goto Masaaki
Higashio Kanji
Kobayashi Fumie
Mochizuki Shin'ichi
Morinaga Tomonori
Arnold & Porter LLP
Daiichi Sankyo Co., Ltd.
Kemmerer Elizabeth C.
LandOfFree
Nucleic acid molecules encoding osteoclastogenesis... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Nucleic acid molecules encoding osteoclastogenesis..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acid molecules encoding osteoclastogenesis... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4033948