Nucleic acid inhibitors of glutamate receptors

Details Nucleic acid inhibitors of glutamate receptors Nucleic acid inhibitors of glutamate receptors

2009-10-13

2011-12-13

Marschel, Ardin (Department: 1636)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C506S016000, C506S013000, C506S023000, C506S007000, C514S04400A

Reexamination Certificate

active

08076467

ABSTRACT:
The present invention relates to novel nucleic acid ligands or aptamers that bind to and inhibit the activation of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors. Also disclosed is a novel combination of technologies, i.e., SELEX and laser pulse photolysis for the selection and screening of aptamers that inhibit receptor function and are useful therefore, in the treatment of diseases associated with excessive activation of ionotropic glutamate receptors.

REFERENCES:
patent: 5270163 (1993-12-01), Gold et al.
patent: 7329742 (2008-02-01), Doyle et al.
Steven M. Shamah et al., “Complex Target SELEX”, Accounts of Chemical Research, Jan. 2008, vol. 41(1), 130-138.
Zhen Huang et al., “RNA Aptamers Selected against the GluR2 Glutamate Receptor Channel”, Biochemistry 2007, vol. 46, 12648-12655.
Marko Djordjevic, “SELEX experiments: New prospects, applications and data analysis in inferring regulatory pathways”, ScienceDirect, Biomolecular Engineering 24 (2007) 179-189.

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