Nucleic acid-containing complex

Details Nucleic acid-containing complex Nucleic acid-containing complex

2007-10-02

2007-10-02

Schnizer, Richard (Department: 1635)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C424S484000

Reexamination Certificate

active

10129906

ABSTRACT:
A nucleic acid-complex, containing a nucleic acid and a positively charged, water-insoluble biodegradable polymer, is disclosed. The complex has properties of sustainedly releasing a desired nucleic acid, especially DNA, to a site. The complex can be taken up by phagocytes such as macrophages and delivered to a target site, allowing the function of the nucleic acid to be exhibited in a target specific manner.

REFERENCES:
patent: 5294249 (1994-03-01), Luisi
patent: 6025337 (2000-02-01), Truong et al.
patent: WO98/01162 (1998-01-01), None
Konishi et al (J. Clin. Invest. 96(2): 1125-1130, 1995).
Quong and Neufield, DNA encapsulation within co-guanidine membrane coated alginate beads and protection from extracapsular nuclease. Journal of Microencapsulation, 16:573-585, 1999.

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