Novel rhodamine derivatives as fluorogenic substrates for protei

Details Novel rhodamine derivatives as fluorogenic substrates for protei Novel rhodamine derivatives as fluorogenic substrates for protei

1985-09-27

1987-02-03

Foelak, Morton

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving hydrolase

435 4, 530345, 530344, 530402, 530407, 530408, 530410, 530409, 530391, 436800, 424 85, C12Q 138, C07K 1714

Patent

active

046408932

ABSTRACT:
The present invention relates to a new class of novel Rhodamine derivatives. These derivatives which are bisamide substitution products are nonfluorescent. Whereas the monoamide substitution products exhibit high fluorescence. Cleavage of a single specified amide bond by bond-specific proteinases will therefore convert the nonfluorescent bisamide derivative into a highly fluorescent monoamide derivative.

REFERENCES:
patent: 2937186 (1960-05-01), Burckhalter et al.
patent: 4433156 (1984-02-01), Ishige et al.
patent: 4436920 (1984-03-01), Sato et al.
Leytus, et al, "New Class of Sensitive and Selective . . . Proteinases" Biochem J., 215, 1983, pp. 253-260.

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