Novel polypeptide and process for producing the same

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Calcitonin; related peptides

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C07K 736

Patent

active

047031069

ABSTRACT:
There are disclosed a novel polypeptide represented by the formula shown below or its acid addition salt or complex: ##STR1## wherein Ala represents alanine, Ser serine, Leu leucine, Thr threonine, Val valine, Gly glycine, Lys lysine, Gln glutamine, Glu glutamic acid, His histidine, Tyr tyrosine, Pro proline, Arg arginine, Asp aspartic acid, and n represents an integer of 3 to 7,
and a process for producing the same comprising forming a peptide or polypeptide represented by the above formula and subjecting the structural units containing a peptide residue represented by the formula: ##STR2## wherein R represents an active ester residue, Ala, Ser, Leu, Thr and n have the same meanings as defined above,
formed in any step of the reaction to cyclization reaction.

REFERENCES:
patent: 4033940 (1977-07-01), Hughes et al.
patent: 4086221 (1978-04-01), Sakakibara et al.
patent: 4239680 (1980-12-01), Hughes et al.
patent: 4277393 (1981-07-01), Sakakibara et al.
patent: 4514331 (1985-04-01), Kaiser et al.

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