Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1976-04-16
1978-02-14
Gerstl, Robert
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
260295R, 2603322A, 2603457P, 2603458P, 2603462, 2603473, 2603474, 2604488R, 26050117, 260514D, 260520B, 260556A, 424275, 424285, 424263, 424308, 424317, 424321, 560 53, 560 60, 560106, 560121, 560255, 542426, C07C17700, A61K 31215, A61K 3119
Patent
active
040739341
ABSTRACT:
Optically active and racemic prostaglandin derivatives of the formula ##STR1## wherein R.sub.1 is --OR.sub.5 ; --NHSO.sub.2 CH.sub.3 ; or --O--CH.sub.2 --U--V; R.sub.5 is hydrogen, alkyl, aryl, or a heterocyclic group; U is a direct bond, carbonyl or carbonyloxy; and V is phenyl substituted by 1-3 phenyl, alkoxy of 1-2 carbon atoms, or halogen, preferably bromine;
R.sub.2 is hydrogen or alkyl of 1-5 carbon atoms;
R.sub.3 is alkyl, substituted or unsubstituted cycloalkyl, straight-chain or branched alkyl of 1-5 carbon atoms substituted by aryl or substituted aryl, when R.sub.1 is as above; or R.sub.3 is aryl or substituted aryl group when R.sub.1 is --OR.sub.5 ', --NHSO.sub.2 CH.sub.3, or --O--CH.sub.2 --U--V and R.sub.5 ' is aryl or a heterocyclic group and U and V are as above;
R.sub.4 is hydrogen or an ether or acyl residue;
A is --CH.sub.2 --CH.sub.2 -- or cis--CH.dbd.CH--;
B is --CH.sub.2 --CH.sub.2 -- or trans--CH.dbd.CH--;
D is a direct bond, oxygen, or sulfur;
Z is carbonyl or >CH OR.sub.4 wherein OR.sub.4 is in the .alpha.- or .beta.-position; and
X y is ##STR2## when Z is >CH OR.sub.4 --, or ##STR3## or --CH.dbd.CH-- when Z is carbonyl; AND, WHEN R.sub.1 is hydroxy, the physiologically compatible salts thereof with bases, have more prolonged activity than naturally-occurring prostaglandins.
Elger Walter
Loge Olaf
Raduechel Bernd
Schillinger Eckehard
Skuballa Werner
Gerstl Robert
Schering Aktiengesellschaft
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