Chemistry: molecular biology and microbiology – Apparatus – Including measuring or testing
Reexamination Certificate
2011-08-30
2011-08-30
Yang, N. C. (Department: 1641)
Chemistry: molecular biology and microbiology
Apparatus
Including measuring or testing
C435S283100, C435S288400, C436S524000, C436S165000, C427S002110, C427S010000, C356S450000
Reexamination Certificate
active
08008068
ABSTRACT:
A nonhemolytic sensor for determination of analytes in erythrocyte-containing biological fluids is disclosed that comprises an optical material having a deposit on a surface thereof, where this deposit includes an analyte-reactive reagent and a particulate means for suppressing hemolysis of erythrocytes in an erythrocyte-containing biological fluid, such as whole blood. Thus, a porous array of negatively charged particles, e.g., polymeric beads having a plurality of carboxylate surface groups, are disposed on a sampling surface of an optical sensor, and suppress hemolysis of erythrocytes coming into contact with the sampling surface. In the case of an optical sensor, such particles can simultaneously enhance reflectance of a light beam transmitted through the optical material to the sampling surface site.
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Carroll David H.
Light Pointe Medical, Inc.
Yang N. C.
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