Nona-peptide and deca-peptide analogs of LHRH, useful as LHRH an

Details Nona-peptide and deca-peptide analogs of LHRH, useful as LHRH an Nona-peptide and deca-peptide analogs of LHRH, useful as LHRH an

1983-03-07

1986-04-08

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C10352

Patent

active

045811695

ABSTRACT:
Synthetic nona-peptide and deca-peptide LHRH antagonist analogs have a novel guanido-substituted, amidine, tertiary or quaternary aminoacyl residue at position 6.

REFERENCES:
patent: 3972859 (1976-08-01), Fujino et al.
patent: 4215038 (1980-07-01), Rivier et al.
patent: 4341767 (1982-07-01), Nestor et al.
Harvath et al., Peptides, 3, 969-971 (1982), printed in USA.
Chemical Abstracts, 88, 631 (1978) Abst. No. 7331j.
Coy et al., Endocrinology, 110 (No. 4), 1445-7 (1982).
Kakimoto et al., J. Biol. Chem., 245 (No. 21), 8751-55 (1970).
W. Beattie, J. of Med. Chem., 18 (No. 12) 1247-1250 (1975).

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