Non-nucleotide reverse transcriptase inhibitors

Details Non-nucleotide reverse transcriptase inhibitors Non-nucleotide reverse transcriptase inhibitors

2011-03-29

2011-03-29

Dentz, Bernard (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S282700, C546S272400, C546S280100, C546S281100, C546S297000

Reexamination Certificate

active

07915295

ABSTRACT:
Compounds of the formula Z: where; A is CH or N; R1is a substituent to a carbon atom in the ring containing A selected from —S(═O)pRa, where Ra is —C1-C4alkyl, —ORx, —NRxRx, —NHNRxRx, —NHNHC(═O)ORx, —NRxOH; —C(═O)—Rb, where Rb is —CT-C4-alkyl, ORx, —NRxRx, —NHNRxRx, —NHC1-C3-alkyl-C(═O)Orx —NRxRc, where Rc is H, C1-C4alkyl, —NRxRx; —C(=0)Rd, —CN, S(═O)pRx, where Rd is Rd is C1-C4-alkyl, —ORx, —NRxRx C1-C3-alkyl-O—C1-C3-alkylC(═O)ORx, —C1-C3-alkyl-COORx; —C1-C3alkyl-OH or C1-C4alkyl ethers or esters thereof (O—C1-C3alkyl)q-O—Rx a 5 or 6 membered aromatic ring having 1-3 hetero atoms p is 1 or 2; Rx is independently selected from H, C1-C4alkyl or acetyl; or a pair of Rx can together with the adjacent N atom form a ring; L is -0-, —S(═O)—, or —CH2—, where r is 0, 1 or 2; R3-R7are substituents as defined in the specification; X is —(CR8R8′)n-D-(CR8R8′)m-; D is a bond, —NR9—, -0-, —S—, —S(=0)- or —S(=0)2-; and pharmaceutically acceptable salts and prodrugs thereof, have utility as HIV antivirals.

REFERENCES:
patent: WO 99/36406 (1999-07-01), None
patent: WO 00/47561 (2000-08-01), None
patent: WO 02/070516 (2002-09-01), None
patent: WO 03/020705 (2003-03-01), None
patent: WO 2004/021969 (2004-03-01), None

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