Non-hormonal method of contraception

Details Non-hormonal method of contraception Non-hormonal method of contraception

1997-09-12

2000-08-29

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

424422, 424430, 424439, 424464, 514841, 514843, A61K 900, A61F 606, A61F 1300

Patent

active

06110471&

ABSTRACT:
A method of contraception by delivering to the ovaries of a female mammal a pharmaceutically-effective dose of a PDE3-specific inhibitor at about the time of ovulation.

REFERENCES:
patent: 4006227 (1977-02-01), Gallegos et al.
patent: 4888350 (1989-12-01), Omodei-Sale'
patent: 5110925 (1992-05-01), Kusase et al.
patent: 5116619 (1992-05-01), Greco et al.
patent: 5276017 (1994-01-01), Feinberg et al.
patent: 5552267 (1996-09-01), Stern et al.
Tsafriri et al, Endocrinology Scoiety, Washington, DC., Abstract P1-153, Jun. 14-17, 1995.
Alvarez, R., et al., "Activation and Selective Inhibition of a Cyclic AMP-Specific Phosphodiesterase, PDE-4D3," Molecular Pharmacology. 48:616-622 (1995).
Conti, M., et al., "Recent Progress in Understanding the Hormonal Regulation of Phosphodiesterases," Endocr. Rev. 16(3):370-389 (1995).
Downs, S.M., and Hunzicker-Dunn, M., "Differential Regulation of Oocyte Maturation and Cumulus Expansion in the Mouse Oocyte-Cumulus Cell Complex by Site-Selective Analogs of Cyclic Adenosine Monophosphate," Dev. Biol. 172:72-85 (1995).
Maller, J.L., "Regulation of Amphibian Oocyte Maturation," Cell. Differ. 16:211-221 (1985).
Reinhardt, R.R., et al., "Distinctive Anatomical Patterns of Gene Expression for cGMP-inhibited Cyclic Nucleotide Phosphodiesterases," J. Clin. Invest. 95:1528-1538 (1995).
Sadler, S.E., "Inhibitors of Phosphodiesterase III Block Stimulation of Xenopus laevis Oocyte Ribosomal S6 Kinase Activity by Insulin-Like Growth Factor-I," Mol. Endocr. 5(12):1947-1954 (1991a).
Sadler, S.E., "Type III Phosphodiesterase Plays a Necessary Role in the Growth-Promoting Actions of Insulin, Insulin-Like Growth Factor-I, and Ha p21ras in Xenopus laevis Oocytes," Mol. Endocr. 5(12):1939-1946 (1991b).
Tsafriri, A., and Dekel, N., "Molecular Mechanisms in Ovulation," in Molecular Biology of the Female Reproductive System (Findlay, J.D., Ed.), pp. 207-258, Academic Press, San Diego (1994).
Tsafriri, A. and Conti, M., "Differential Inhibition of Phosphodiesterases in the Somatic and Oocyte Compartmens of Rat Follicles: Involvement in Oocyte Maturation," Endocrine Society, 77th Annual Meeting, Washington D.C. (Poster Sessions, P1-153, p. 151) Jun. 14-17, (1995).
Tsafriri, A., et al., "Oocyte Maturation Involves Compartmentalization and Opposing Changes of cAMP Levels in Follicular Somatic and Germ Cells: Studies Using Selective Phosphodiesterase Inhibitors," Dev. Biol. 178: 393-402 (1996).

Affiliated with

Also associated with

Rating

Non-hormonal method of contraception does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Non-hormonal method of contraception, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Non-hormonal method of contraception will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1246771