Non-anaphylactic forms of allergens and their use

Details Non-anaphylactic forms of allergens and their use Non-anaphylactic forms of allergens and their use

2006-09-19

2006-09-19

Nolan, Patrick J. (Department: 1644)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Allergen or component thereof

C530S370000, C530S868000, C514S327000

Reexamination Certificate

active

07108858

ABSTRACT:
The present invention is drawn to an immunogen derived from a protein allergen, which is a) a non-anaphylactic immunogenic recombinant fragment of the protein allergen which contains an IgG epitope partly but not wholly overlapping an IgE epitope of the protein allergen; b) a polymeric form of the fragment, in which the fragment constitutes the monomeric units; or c) a non-anaphylactic recombinant polymeric form of the protein allergen having 2–10 monomeric units, in which the protein allergen constitutes the monomeric units. The present invention is further drawn to the use of the immunogen for in vitro diagnoses of type I allergy and hyposensitization.

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