Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Reexamination Certificate
2004-10-29
2009-12-08
Shiao, Rei-tsang (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
C558S166000, C558S177000
Reexamination Certificate
active
07629332
ABSTRACT:
The present invention relates to a novel nitrophenyl mustard and nitrophenylaziridine alcohols, to their corresponding phosphates, to their use as targeted cytotoxic agents; as bioreductive drugs in hypoxic tumors, and to their use in cell ablation, including gene-directed enzyme-prodrug therapy (GPEPT) and antibody-directed enzymeprodrug therapy (ADEPT), in conjunction with nitroreductase enzymes.
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Atwell Graham John
Denny William Alexander
Helsby Nuala Ann
Patterson Adam Vorn
Wilson William Robert
Auckland Uniservices Limited
Nixon & Vanderhye
Shiao Rei-tsang
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