Nitro-substituted polycyclic derivatives useful in the treatment

Details Nitro-substituted polycyclic derivatives useful in the treatment Nitro-substituted polycyclic derivatives useful in the treatment

1982-02-04

1983-12-06

Rivers, Diana G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546 51, A61K 31435, C07D46100

Patent

active

044193599

ABSTRACT:
The present invention relates to the compounds of the Formulae 1a and 1b and pharmaceutically acceptable acid addition salts thereof.
The new 9-nitro-apovincaminol-3',4',5'-trimethoxybenzoate of the Formula 1a ##STR1## and the 11-nitro-apovincaminol-3',4',5'-trimethoxy-benzoate of the Formula 1b ##STR2## and pharmaceutically acceptable acid addition salts thereof can be prepared by nitrating the apovincaminol-3',4',5'-trimethoxy-benzoate of the Formula 11, ##STR3## if desired separating the mixture of the compounds of the Formulae 1a and 1b thus obtained into its components, if desired converting a compound of the Formula 1a or 1b thus obtained into pharmaceutically acceptable acid addition salts thereof.
The new compounds of the present invention can be used in therapy in the treatment of psoriasis.

REFERENCES:
patent: 4065458 (1977-12-01), Lorincz et al.
patent: 4108996 (1978-08-01), Lorincz et al.
patent: 4328231 (1982-05-01), Zajer nee Balazs et al.
Lorincz et al., Chemical Abstracts, vol. 82, 129279v, (1975).

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