Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2005-02-22
2005-02-22
Peselev, Elli (Department: 1623)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C514S519000, C536S004100, C558S303000
Reexamination Certificate
active
06858588
ABSTRACT:
The present invention relates to a novel nitrile glycoside of Formula I named NIAZIRIDIN and to analogues and derivatives thereof. The present invention also relates to a process for the isolation of a novel nitrile glycoside of Formula I below named NIAZIRIDIN and its derivatives and analogues by bioactivity-guided fractionation from the pods ofMoringa oleifera.The present invention particularly relates to the bioenhancing activity of the novel nitrile glycoside of Formula I below named NIAZIRIDIN and its derivatives and analogues in enhancing bioactivity of commonly used antibiotics such as rifampicin, tetracycline and ampicillin against Gram (+) and (−) bacteria. The biomolecule also enhances the absorption of drugs, vitamins and nutrients through the gastro-intestinal membrane increasing their bio-availability. Therefore niaziridin can be used in combination therapy with drugs and nutrients resulting in reduced drug associated toxicity, reduced cost and duration of chemotherapy.
REFERENCES:
patent: 20020151505 (2002-10-01), Fahey
Guevara et al. (Mutation Research (1999), 440 (2), 181-188) (Abstract Sent).*
Leuck et al. (Carbohydrate Research (1998), 312 (1-2), 33-44). (Abstract Sent).*
A.P. Guevara et al.; “An Antitumor Promoter from Moringa Oleifera Lam”; Mutation Research, Amsterdam, NL, vol. 440, No. 2, 1999, pp. 181-188, XP001128727; ISSN: 0027-5107, p. 182.
U. Eilert et al.; “The Antibiotic Principle of Seeds of Moringa Oleifera and Moringa Stenopetala”; Planta Medica (1981), 42(1), 55-61, 1981 XP009024217 The Whole Document.
Akira Mukakami, et al.; “Niaziminin, A Thiocarbamate from The Leaves of Moringa Oleifera, Holds A Strick . . . Activation” Planta Medica (1998): 64(4), 319-323, 1998, XP009024218, The Whole Document.
Michael Leuck et al.; “Synthesis of Active Principles from the Leaves of Moringa Oleifera . . . Enylthiolgycosides” Carbohydrate Research (1998), 312(1-2), 33-44, 1998, XP004204817, The Whole Document.
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Arya Jai Shanker
Darokar Mahendra Pandurang
Gupta Madan Mohan
Gupta Subhash Chandra
Kaur Harpreet
Council of Scientific and Industrial Research
Henry Michael C.
Ladas & Parry
Peselev Elli
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