Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Reexamination Certificate
2005-01-25
2009-11-24
Saeed, Kamal A (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
C514S165000, C514S533000, C558S275000, C560S011000
Reexamination Certificate
active
07622501
ABSTRACT:
The invention encompasses novel compounds of Formula I, which are nitric oxide-releasing prodrugs of diaryl-2-(5H)-furanones useful in the treatment of cyclooxygenase-2 mediated diseases, Formula (I). The invention also encompasses certain pharmaceutical compositions and methods for treating cyclooxygenase-2 mediated diseases comprising the use of compounds of Formula 1. The above compounds may be used as a combination therapy with low-dose aspirin to treat chronic cyclooxygenase-2 mediated diseases or conditions while also reducing the risk of thrombotic cardiovascular events.
REFERENCES:
patent: 7199154 (2007-04-01), Berthelette et al.
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patent: WO 97/28120 (1997-08-01), None
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patent: WO 01/45703 (2001-06-01), None
patent: WO 03/084550 (2003-10-01), None
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Aspiotis Renee
Berthelette Carl
Dufresne Claude
Gallant Michel
Guay Daniel
Camara Valerie J.
Merck Frosst Canada & Co.
Panzer Curtis C.
Rodriguez-Garcia Valerie
Saeed Kamal A
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