Nitric oxide releasing prodrugs of diaryl-2-(5H)-furanones...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai

Reexamination Certificate

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Details

C514S165000, C514S533000, C558S275000, C560S011000

Reexamination Certificate

active

07622501

ABSTRACT:
The invention encompasses novel compounds of Formula I, which are nitric oxide-releasing prodrugs of diaryl-2-(5H)-furanones useful in the treatment of cyclooxygenase-2 mediated diseases, Formula (I). The invention also encompasses certain pharmaceutical compositions and methods for treating cyclooxygenase-2 mediated diseases comprising the use of compounds of Formula 1. The above compounds may be used as a combination therapy with low-dose aspirin to treat chronic cyclooxygenase-2 mediated diseases or conditions while also reducing the risk of thrombotic cardiovascular events.

REFERENCES:
patent: 7199154 (2007-04-01), Berthelette et al.
patent: WO 95/30641 (1995-11-01), None
patent: WO 97/28120 (1997-08-01), None
patent: WO 98/09948 (1998-03-01), None
patent: WO 01/45703 (2001-06-01), None
patent: WO 03/084550 (2003-10-01), None
patent: WO 03/103602 (2003-12-01), None
patent: WO 2004/002420 (2004-01-01), None
patent: WO 2004/011421 (2004-02-01), None
patent: WO 2004/103955 (2004-12-01), None

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