Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form
Reexamination Certificate
2005-05-03
2005-05-03
Page, Thurman K. (Department: 1615)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
C424S718000, C424S422000, C424S423000, C424S078270
Reexamination Certificate
active
06887485
ABSTRACT:
Biocompatible metallic medical devices having silanized surfaces coupled to nucleophile residues that release sustained, therapeutic amounts of nitric oxide to specific sites within a mammalian body are provided. Additionally, the biocompatible metallic medical devices can also be provided with anti-thrombogenic, lubricious coatings that release sustained, therapeutic amounts of nitric oxide. Moreover, the silanized metallic devices are surprisingly durable when exposed to harsh chemical methods often needed to bind nitric oxide-releasing functional groups to nucleophile residues. Furthermore, methods are provided for producing stable, silanized, sustained nitric oxide-releasing metallic medical devices.
REFERENCES:
patent: 4954526 (1990-09-01), Keefer
patent: 5039705 (1991-08-01), Keefer et al.
patent: 5155137 (1992-10-01), Keefer et al.
patent: 5171217 (1992-12-01), March et al.
patent: 5212204 (1993-05-01), Keefer et al.
patent: 5229172 (1993-07-01), Cahalan et al.
patent: 5250550 (1993-10-01), Keefer et al.
patent: 5268465 (1993-12-01), Bredt et al.
patent: 5356433 (1994-10-01), Rowland et al.
patent: 5366997 (1994-11-01), Keefer et al.
patent: 5380758 (1995-01-01), Stamler et al.
patent: 5405919 (1995-04-01), Keefer et al.
patent: 5428070 (1995-06-01), Cooke et al.
patent: 5468630 (1995-11-01), Billiar et al.
patent: 5482925 (1996-01-01), Hutsell
patent: 5519020 (1996-05-01), Smith et al.
patent: 5525357 (1996-06-01), Keefer et al.
patent: 5574068 (1996-11-01), Stamler et al.
patent: 5583101 (1996-12-01), Stamler et al.
patent: 5632981 (1997-05-01), Saavedra et al.
patent: 5650447 (1997-07-01), Keefer et al.
patent: 5658565 (1997-08-01), Billiar et al.
patent: 5676963 (1997-10-01), Keefer et al.
patent: 5683668 (1997-11-01), Hrabie et al.
patent: 5691423 (1997-11-01), Smith et al.
patent: 5700830 (1997-12-01), Korthuis et al.
patent: 5714511 (1998-02-01), Saavedra et al.
patent: 5718892 (1998-02-01), Keefer et al.
patent: 5721365 (1998-02-01), Keefer et al.
patent: 5770645 (1998-06-01), Stamler et al.
patent: 5789447 (1998-08-01), Wink, Jr. et al.
patent: 5814656 (1998-09-01), Saavedra et al.
patent: 5814667 (1998-09-01), Mitchell et al.
patent: 5837313 (1998-11-01), Ding et al.
patent: 5837736 (1998-11-01), Mitchell et al.
patent: 5840759 (1998-11-01), Mitchell et al.
patent: 5873904 (1999-02-01), Ragheb et al.
patent: 5877216 (1999-03-01), Place et al.
patent: 5891459 (1999-04-01), Cooke et al.
patent: 5910316 (1999-06-01), Keefer et al.
patent: 5945452 (1999-08-01), Cooke et al.
patent: 5958427 (1999-09-01), Salzman et al.
patent: 5962520 (1999-10-01), Smith et al.
patent: 5994444 (1999-11-01), Trescony et al.
patent: 6024918 (2000-02-01), Hendriks et al.
patent: 6171232 (2001-01-01), Papandreou et al.
patent: 6270779 (2001-08-01), Fitzhugh et al.
patent: 0992252 (2000-04-01), None
patent: 0 992 252 (2000-04-01), None
patent: WO 0002501 (2000-01-01), None
patent: WO 0030658 (2000-06-01), None
patent: WO 0110344 (2001-02-01), None
Pulfer et a1.; Incorporation of Nitric Oxide-Releasing Crosslinked Polyethyleneimine Microspheres Into Vascular Grafts; Journal of Biomedical Materials Research. Wilev. New York. NY. vol. 37. No. 2. Nov. 1997 f:pp 182-189.*
Bauer et al.; Evaluation of Linear Polyethyleneimine
itric Oxide Adduct on Wound Repair: Therapy versus Toxicity; Wound Repair & Regeneration, Nov./Dec. 1998, pp. 569/577.
Hanson et al.; Nitric Oxide Donors: A Continuing Opportunity in Drug Design; Advances in Pharmacology, vol. 34, pp. 383/398.
Jordi; Jordi Gel Columns for Size Exclusion Chromatography; Column Handbook for Size Exclusion Chromotography; 1999, pp. 367/425.
Downey et al.; Growth Mechanism of Poly(divinylbenzene) Microspheres in Precipitation Polymerization; American Chemical Society, Easton, US, vol. 32, No. 4, May 4, 1999; pp. 2838-2844.
Pulfer et al.; Incorporation of Nitric Oxide-Releasing Crosslinked Polyethyleneimine Microspheres Into Vascular Grafts; Journal of Biomedical Materials Research; Wiley, New York, NY, vol. 37, No. 2, Nov. 1997; pp/ 182-189.
Zhang et al.; Synthesis of Nitric Oxide Releasing Silicone Rubbers for Biomedical Applications; Polymer Preprints; vol. 40, No. 2, 1999, pp. 799-800.
Kaul et al.; Polymeric/Based Perivascular Delivery of a Nitric Oxide Donor Inhibits Intimal Thicening After Balloon Denudation Arterial Injury: Role of Nuclear Factor/kappaB; Journal of the American College of Cardiology, vol. 35, No. 2, 2000:493/501.
Mowery et al.; Preparation and Characterization of Hydrophobic Polymeric Films That Are Thromboresistant Via Nitric Oxide Release; Biomaterials 21 (2000) 9/21.
Smith et al.; Nitric Oxide/Releasing Polymers Containing the [N(O)NO] Group; J.Med.Chem. 1996, 39, 1148/1156.
Keefer, et al; “NONOates” (1-Substituted Diazen-1-ium-1,2-diolates) as Nitric Oxide Donors: Convenient Nitric Oxide Dosage Forms. Methods in Enzymology, vol. 268: 281-293, Jul. 1996.
Saavedra, et al.; “Conversion of Polysaccharide to Nitric Oxide-Releasing Form Dual-Mechanism Anticoagulant Activity of Diazeniumdiolated Heparin.” Bioorganic & Medicinal Chemistry Letters 10 (2000) 1-3.
Hrabie, et al; “New Nitric Oxide-Releasing Zwitterions Derived from Polyamines.” J. Org. Chem. 1993, 58, 1472-1476.
Chandy, et al; “Use of Plasma Glow for Surface-Engineering Biomolecules to Enhance Bloodcompatibility of Dacron and PTFE Vascular Prosthesis.” Biomaterials 21 (2000): 699-712.
Drago, Russell S.; “Reactions of Nitrogen(II) Oxide” No. 36, Advances in Chemistry Series, American Chemical Society, Washington, D. C. 1962, pp. 143-149.
Cafferata Robert
Cheng Peiwen
Fitzhugh Anthony L.
Hendriks Marc
Keefer Larry K.
Fubara Blessing
Medtronic Vascular Inc.
Page Thurman K.
The United States of America as represented by the Department of
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