Nitric oxide donor compounds

Details Nitric oxide donor compounds Nitric oxide donor compounds

2011-08-23

2011-08-23

Desai, Rita (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S321000

Reexamination Certificate

active

08003811

ABSTRACT:
The invention relates to nitric oxide donors of the formula (I) and pharmaceutically acceptable salts or stereoisomers thereof:wherein A and A′ are independently selected from the group consisting of H and —(X)s—Y with the proviso that at least one of A or A′ is not H;whereins is 0 or 1;X is selected from the group consisting of:—CO—, —COO—, —CONH— and —SO2— orY isstraight or branched C1-C20alkyl chain, preferably C1-C10alkyl chain, substituted with one or two —ONO2; orC1-C6alkylenoxy-C1-C5alkyl wherein the alkyl group is substituted by one or two —ONO2groups.The invention also provides novel compositions comprising at least one compound of the invention and at least one therapeutic agent.

REFERENCES:
patent: 0 361 156 (1990-04-01), None
Stoss et al Arzneimittel-Forschung 1990, 40, 13-18.
Miller M R et al: “Recent developments in nitric oxide donor drugs.” British Journal of Pharmacology Jun. 2007, vol. 151, No. 3, Jun. 2007 pp. 305-321, XP00252052 ISSN: 0007-1188.
Megson Ian L et al: “Nitric oxide donor drugs: current status and future trends.” Expert Opinion on Investigational Drugs May 2002, vol. 11, No. 5, May 2002, pp. 587-601, XP002520653 ISSN: 1354-3787.

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