NIMA interacting proteins

Details NIMA interacting proteins NIMA interacting proteins

2006-10-24

2006-10-24

Siew, Jeffrey (Department: 1642)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

C530S350000, C435S183000, C435S233000

Reexamination Certificate

active

07125955

ABSTRACT:
A novel class of NIMA interacting proteins (PIN), exemplified by Pin1, is provided. Pin1 induces a G2 arrest and delays NIMA-induced mitosis when overexpressed, and triggers mitotic arrest and DNA fragmentation when depleted. Methods of identifying other Pin proteins and Pin-interacting proteins and identifying compositions which affect Pin activity or expression are also provided.

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