Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2004-02-13
2010-11-23
Nickol, Gary B. (Department: 1647)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S326000, C514S315000
Reexamination Certificate
active
07838539
ABSTRACT:
The present invention features methods for recruitment of bone marrow-derived stem cells (e.g., endothelial cell precursors, hematopoietic stem cells) by administration of nicotine or other nicotine receptor agonist. The methods of the invention can be used in, for example, treatment of conditions amenable to treatment by recruitment of bone marrow-derived stem cells (e.g., neutropenia).
REFERENCES:
patent: 4321387 (1982-03-01), Chavdarian et al.
patent: 4332945 (1982-06-01), Edwards, III
patent: 4442292 (1984-04-01), Edwards, III
patent: 4452984 (1984-06-01), Edwards, III
patent: 4590278 (1986-05-01), Edwards, III
patent: 4725609 (1988-02-01), Kull, Jr. et al.
patent: 4920989 (1990-05-01), Rose et al.
patent: 4943435 (1990-07-01), Baker et al.
patent: 5055478 (1991-10-01), Cooper et al.
patent: 5318957 (1994-06-01), Cid et al.
patent: 5508030 (1996-04-01), Bierman
patent: 5695755 (1997-12-01), Papayannopoulou
patent: 5866561 (1999-02-01), Ungs
patent: 5869037 (1999-02-01), Crystal et al.
patent: 6465709 (2002-10-01), Sun et al.
patent: 6500418 (2002-12-01), Dieckgraefe et al.
patent: 6720340 (2004-04-01), Cooke et al.
patent: 2001/0034023 (2001-10-01), Stanton et al.
patent: 2005/0033522 (2005-02-01), Wainer et al.
patent: 2004135582 (2004-05-01), None
patent: WO 97/34605 (1997-09-01), None
patent: WO 9734605 (1997-09-01), None
patent: WO 00/23062 (2000-04-01), None
patent: WO 01/08683 (2000-07-01), None
Totti et al. “Nicotine Is Chemotactic for Neutrophils and Enhances Neutrophil Responsiveness to Chemotactic Peptides.” Science. 1984. No. 223. vol. 4632. pp. 169-171.
Villablanca, Amparo C. “Nicotine stimulates DNA synthesis and proliferation in vascular endothelial cells in vitro.” Journal of American Physiology. 1998. pp. 2089-2098.
Powell, JT. “Vascular damage from smoking: disease mechanisms at the aterial wall”. Vascular Medicine. 1998. vol. 3. pp. 21-28.
Villablanca, AC. “Nicotine stimulates DNA synthesis and proliferation in vascular endothelial cells in vitro”. Journal of Applied Physiology. 1998. vol. 84. No. 6. pp. 2089-2098.
Testa et al., Predicting drug metabolism: Concepts and challenges, 2004, Pure Appl.Chem, vol. 76, No. 5, 907-914.
Pandit et al., Sustained Exposure to Nicotine Leads to Extramedullary Hematopoiesis in the Spleen, 2006, Stem Cells, 24, 2373-2381.
Briggs, HIV vaccine research hits impasse, 2008, BBC News, http:/
ews.bbc.co.uk/go/pr/fr/-/2/hi/science
ature/7246117.stm, 2 pages.
Merck Manuals, Neutropenia, Merck Manuals, http://www.merck.com/mmpe/print/sec11/ch132/ch132v.html, 9 pages.
MedicineNet.com, Sharp Debate over HIV Vaccine Failure, 2008, http://www.medicinenet.com/script/main/art.asp?articlekey=88165&pf=3&page=1, 3 pages.
Wognum et al., Identification and Isolation of Hematopoietic Stem Cells, 2003, Archives of Medical Research, 34, 461-475.
Crothers et al., The Impact of Cigarette Smoking on Mortality, Quality of Life, and Comorid Illness Among HIV-Positive Veterans, 2005, J Gen Intern Med, 20:1142-1145.
Benowitz et al., Daily intake of nicotine during cigarette smoking, 1984, Clinical Pharmacology and Therapeutics, 35, Abstract only, printed from http://www.nature.com/cIpt/journal/v35
4/abs/cIpt198467a.html on 829/2009, 2 pages.
Armitage et al., Absorption and metabolism of nicotine from cigarettes, 1975, Br Med J , 4:313-316.
Nieman et al., The effect of cigarette smoking on the development of AIDS in HIV-1-seropositive individuals, AIDS, 1993, 7:705- 710.
Galai et al., Existence and failure of T-cell homeostasis prior to AIDS onset in HIV-infected injection drug users,1996, Clinical Immunology and Immunopathology, vol. 79, No. 2, 134-141.
Park et al., Influence of HIV-1 infection and cigarette smoking on leukocyte profiles in homosexual men. The Multicenter AIDS Cohort Study, 1992, J Acquir Immune Defic Syndr, 5(11), Abstract only, printed on Aug. 29, 2009 from http://www.ncbi.nlm.nih.gov/pubmed/1403643?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed—ResultsPanel.Pubmed, 2 pages.
Cancer.Net-Oncologist-aprroved cancer information from the American Societ of Clinical Oncology, Leukemia—Acute Myeloid—AML, printed Aug. 29, 2009 from http://www.cancer.net/patient/Cancer+Types/Leukemia+−+Acute+Myeloid+−+AML?sectionTitle=Overview, 2 pages.
Chelghoum et al., Influence of cigarette smoking on the presentation and course of acute myeloid leukemia, 2002 Oct., Ann Oncol, 13(10):1621-7.
Videtic et al., Continued Cigarette Smoking by Patients Receiving Concurrent Chemoradiotherapy for Limited-Stage Small-Cell Lung Cancer Is Associated With Decreased Survival, 2003, Journal of Clinical Oncology, vol. 21, Issue 8 (Apr.),1544-1549.
Iho et al., Journal of Leukocyte Biology. 2003;74:942-951.
Pabst et al., J Periodontol. Dec. 1995;66(12):1047-1055; Abstract only.
Geng et al., (Toxicol Appl Pharmacol. Dec. 1995;135(2):268-278).
Heimke et al., Neurosci Lett. Aug. 23, 1996;214(2-3):171-174.
Flammia et al., J Med Chem. Sep. 9, 1999;42(18):3726-3731.
Ding et al., Cytokine, Jan. 1997, 9 (1), 59-65.
Heeschen, Christopher et al. “Nicotine is an agent of angiogenesis: Role of Nitric Oxide and Prostacyclin”, Journal of the American College of Cardiology, vol. 35, No. 2, Suppl. A, Feb. 2000, pp. 545A-546A; XP001180280, 29thAnnual Scientific Session of the American College of Cardiology, Anaheim, CA, USA, Mar. 12-15, 2000, ISSN: 0735-1097.
Heeschen et al. ((2001) “Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis.”Nat MedJul.; 7(7):833-9).
Jacobi et al. ((2001) “Nicotine stimulates wound healing in diabetic mice.”Am J PatholJul.;161(1):97-104).
Heeschen et al. ((2003) “Nicotine promotes arteriogenesis.”J Am Coll Cardiol, Feb. 5;41(3):489-96).
Heeschen et al. ((2002) “A Novel angiogenic pathway mediated by non-neuronal nicotine acetylcholine receptors.”J. Clin InvestAug.;110(4):527-36).
Zhu et al. ((2003) “Second hang Smoke Stimulates Tumor Angiogenesis and Growth.” Cancer Cell 4(3):191-6).
Kondo et al. (2003)Ann. Rev. Immunol. 21:759-806.
Prohaska et al. (2002)Semin. Immunol. 14:377-384.
Kondo eta l. (2001)Curr. Opin. Genet. Dev. 11:520-526.
Weissman et al. (2001)Ann. Rev. Cell Dev. Biol. 17:387-403.
Takahashi, et al., “Continine (A Metabolite of Nicotine) Suppresses the Growth of Hematopoietic Progenitor Cells at the Concentration Range Equivalent to Its Serum Levels in Smokers” Stem Cells, 1999;17:125-126.
Khaldoyandidi, et al., “Correlation Between Nicotine-Induced Inhibition of Hematopoiesis and Decreased CD44 Expression on Bone Marrow Stomal Cells” Blood, Jul. 15, 2001, vol. 98, No. 2.
Aituri, et al. “Functional Nicotonic Acetylcholine Receptor Expression in Stem and Progenitor Cells of the Early Embryonic Mouse Cerebral Cortex” Center for Neuropharmacology and Neuroscience, Albany Medical College, Developmental Biology 240, 143-156 (2001).
Abood et al. (1988). “Structure-Activity Studies of Carbamate and other Esters: Agonists and Antagonists to Nicotine.”Pharmacology Biochemistry&Behavior, vol. 30: 403-408.
Belluardo et al. (1998). “Acute intermittent nicotine treatment produces regional increases of basic fibroblast growth factor messenger RNA and protein in the tel-and diencephalon of the rat”Neuroscience, vol. 83(3): 723-740.
Carty et al. (1996). “Nicotine and cotinine stimulate secretion of basic fibroblast growth factor and affect expression of matrix metalloproteinases in cultured human smooth muscle cells”J. of Vascular Surgery, vol. 24(6): 927-934.
Cucina et al. (1999). “Nicotine regulates basic fibroblast growth factor and transforming growth factor μ, production in endothelial cells”Biochem. and Biophys. Res. Comm., vol. 257: 306-312.
Damaj et al. (1998). “Antinociceptive responses to nicotinic acetylcholine receptor ligands after systemic and intrathecal administration in mice”J. of Pharmacology and Exp
Cooke John
Heeschen Christopher
Jang James
Johnson Frances Lauri
Pathak Anjali
Borden Paula A.
Bozicevic Field & Francis LLP
Gamett Daniel C
Nickol Gary B.
The Board of Trustees of the Leland Stanford Junior University
LandOfFree
Nicotine receptor agonists in stem cell and progenitor cell... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Nicotine receptor agonists in stem cell and progenitor cell..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nicotine receptor agonists in stem cell and progenitor cell... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4197884