New tunicamine derivatives and their preparation

Details New tunicamine derivatives and their preparation New tunicamine derivatives and their preparation

1978-06-29

1980-05-13

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 17R, 424180, C07H 1700

Patent

active

042029686

ABSTRACT:
New tunicamine derivatives are provided which exhibit antiviral activity against some virus, particularly Newcastle disease virus, and inhibitory activity against coccidiosis and which are also of particular value as intermediates for the preparation of a variety of useful antibacterial, antitumor and antiviral compounds. They have a structure of the formula: ##STR1## wherein R represents hydrogen or a fatty acid residue of the formula (CH.sub.3).sub.2 CH(CH.sub.2).sub.n CH.dbd.CHCO-- where n represents an integer of 8 to 11 inclusive. They are prepared either by fermentation methods or by acid hydrolysis of the known antibiotic tunicamycin.

REFERENCES:
Omura, S., J. of Antibiotics, 27(2), 1974, pp. 147-149.

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