New renin-inhibitory oligopeptides, their preparation and their

Details New renin-inhibitory oligopeptides, their preparation and their New renin-inhibitory oligopeptides, their preparation and their

1993-07-30

1995-01-03

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 19, 530331, A61K 3702, C07K 508

Patent

active

053786904

ABSTRACT:
Oligopeptides of formula (I): ##STR1## where R.sup.1 -R.sup.5 are various organic groups, and A represents a group of formula --NH-- or --(CH.sub.2).sub.n --, in which n represents an integer of from 1 to 3, have renin-inhibitory activity and are particularly suitable for oral administration. They may be prepared by condensing their component amino acids or lower oligopeptides using conventional peptide synthesis reactions.

REFERENCES:
patent: 4548926 (1985-10-01), Matsueda et al.
patent: 4698329 (1987-10-01), Matsueda et al.
Burger, Medicinal Chemistry, 1960, pp. 565-571, 578-581, 600-601.
Plattner et al. J. Med. Chem. 1988, 31(12):2277-2288.
Denkewalter et al. Progress In Drug Research, 1966, vol. 10:510-512.
Haber et al. J. Cardiovasc. Res. 1987, 10 (Suppl. 7):S54-S58.
Bolis et al. J. Med. Chem. 1987, 30(10):1729-1737.

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